Source:http://linkedlifedata.com/resource/pubmed/id/15684717
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2005-2-1
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pubmed:abstractText |
The murine Nd1 gene encodes two forms of protein, Nd1-L and Nd1-S, both of which share the BTB/POZ domain, but Nd1-S lacks the kelch repeats. Although Nd1-L ubiquitously expresses, localizes in the cytoplasm and functions as a stabilizer of actin filaments, expression and function of Nd1-S were unknown. Here we show that Nd1-S were expressed in all tissues examined and localized in the nucleus as a speckled-like pattern. Furthermore, overexpression of Nd1-S perturbed cell growth of NIH3T3 cells at the G1/S phase of the cell cycle. These results suggest that Nd1-S may play a role in cell cycle progression in the nucleus.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1044-5498
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
30-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15684717-Animals,
pubmed-meshheading:15684717-Cell Cycle,
pubmed-meshheading:15684717-Cell Nucleus,
pubmed-meshheading:15684717-Cell Proliferation,
pubmed-meshheading:15684717-Fibroblasts,
pubmed-meshheading:15684717-Gene Expression,
pubmed-meshheading:15684717-Mice,
pubmed-meshheading:15684717-NIH 3T3 Cells,
pubmed-meshheading:15684717-Proteins,
pubmed-meshheading:15684717-RNA, Messenger,
pubmed-meshheading:15684717-Tissue Distribution,
pubmed-meshheading:15684717-Transfection
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pubmed:year |
2005
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pubmed:articleTitle |
Overexpression of Nd1-s, a variant form of new kelch family protein, perturbs the cell cycle progression of fibroblasts.
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pubmed:affiliation |
Department of Developmental Genetics (H2), Graduate School of Medicine, Chiba University, Chiba, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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