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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2005-2-9
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pubmed:abstractText |
Liver receptor homolog 1 (LRH-1) is an orphan nuclear receptor that synergizes with beta-catenin/T cell factor 4 signaling to stimulate intestinal crypt cell renewal. We evaluated here the impact of haploinsufficiency of LRH-1 on intestinal tumorigenesis by using two independent mouse models of human colon tumorigenesis. Haploinsufficiency of LRH-1 blunts intestinal tumorigenesis in the ApcMin/+ mice, a genetic model of intestinal cancer. Likewise, Lrh-1+/- mice are protected against the formation of aberrant crypt foci in the colon of mice exposed to the carcinogen azoxymethane. LRH-1 gene expression is reduced in tumors that express elevated levels of the proinflammatory cytokine TNF-alpha. Reciprocally, decreased LRH-1 expression in Lrh-1+/- mice attenuates TNF-alpha expression. Compared with normal human colon, expression and subcellular localization of LRH-1 is significantly altered in neoplastic colon. In combination, these data suggest a role of LRH-1 in the initiation of intestinal tumorigenesis both by affecting cell cycle control as well as through its impact on inflammatory pathways.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15684064-10201372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15684064-10224221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15684064-10318916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15684064-10559496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15684064-11108279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15684064-11145965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15684064-11429595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15684064-12446566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15684064-12519762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15684064-12820970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15684064-12853459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15684064-12972182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15684064-12972592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15684064-1338904,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15684064-1350108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15684064-1448096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15684064-15014077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15684064-15117876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15684064-15130581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15684064-15194558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15684064-15294155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15684064-15327767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15684064-1651174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15684064-1651563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15684064-2296722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15684064-2733382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15684064-3545431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15684064-6733565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15684064-8208295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15684064-8247073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15684064-8608874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15684064-8668203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15684064-8861899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15684064-8972226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15684064-9727977
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
102
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2058-62
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15684064-Animals,
pubmed-meshheading:15684064-Azoxymethane,
pubmed-meshheading:15684064-Carcinogens,
pubmed-meshheading:15684064-Cell Cycle,
pubmed-meshheading:15684064-Disease Models, Animal,
pubmed-meshheading:15684064-Female,
pubmed-meshheading:15684064-Heterozygote,
pubmed-meshheading:15684064-Humans,
pubmed-meshheading:15684064-Inflammation,
pubmed-meshheading:15684064-Intestinal Neoplasms,
pubmed-meshheading:15684064-Male,
pubmed-meshheading:15684064-Mice,
pubmed-meshheading:15684064-Mice, Inbred C57BL,
pubmed-meshheading:15684064-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:15684064-Tumor Necrosis Factor-alpha
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pubmed:year |
2005
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pubmed:articleTitle |
Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammation.
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pubmed:affiliation |
Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique/Institut National de la Santé et de la Recherche Médicale/Université Louis Pasteur, 67404 Illkirch, France.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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