Source:http://linkedlifedata.com/resource/pubmed/id/15683478
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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
2005-2-1
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pubmed:abstractText |
The flecainide infusion test has been proposed to screen candidates for hybrid pharmacological and ablation therapy. We report the long-term follow-up of 154 consecutive patients with paroxysmal or persistent atrial fibrillation (AF) who developed atrial flutter (AFL) during flecainide infusion (IC AFL), treated with inferior vena cava-tricuspid annulus isthmus catheter ablation and oral flecainide (hybrid therapy). Over a mean of 54.1 +/- 13.1 months 82 patients (53%) remained free of AF and AFL. Flecainide was discontinued because of adverse effects in 6 patients (4%). A history of persistent AF, and the documentation of >/=1 spontaneous AFL episode before the flecainide test were independent predictors of successful hybrid therapy. In patients with paroxysmal AF without documented spontaneous AFL, the long-term efficacy of hybrid therapy was 38.5% (P = 0.03). The flecainide infusion test reliably detects candidates for hybrid therapy. The efficacy of this therapy is maintained over the long-term with a high patient compliance.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0147-8389
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pubmed:author |
pubmed-author:AstaritaCostantinoC,
pubmed-author:De MatteisCarmineC,
pubmed-author:De SimoneAntonioA,
pubmed-author:Di NapoliTommasoT,
pubmed-author:El JamalBilalB,
pubmed-author:GrecoLucianoL,
pubmed-author:La RoccaVincenzoV,
pubmed-author:MessinaVincenzoV,
pubmed-author:NocerinoPasqualeP,
pubmed-author:RotunnoRaffaeleR,
pubmed-author:StabileGiuseppeG,
pubmed-author:TurcoPietroP,
pubmed-author:VitaleDino FrancoDF
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pubmed:issnType |
Print
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pubmed:volume |
28 Suppl 1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
S124-7
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pubmed:meshHeading |
pubmed-meshheading:15683478-Anti-Arrhythmia Agents,
pubmed-meshheading:15683478-Atrial Fibrillation,
pubmed-meshheading:15683478-Atrial Flutter,
pubmed-meshheading:15683478-Catheter Ablation,
pubmed-meshheading:15683478-Combined Modality Therapy,
pubmed-meshheading:15683478-Female,
pubmed-meshheading:15683478-Flecainide,
pubmed-meshheading:15683478-Follow-Up Studies,
pubmed-meshheading:15683478-Humans,
pubmed-meshheading:15683478-Infusions, Intravenous,
pubmed-meshheading:15683478-Male,
pubmed-meshheading:15683478-Middle Aged,
pubmed-meshheading:15683478-Recurrence,
pubmed-meshheading:15683478-Time Factors
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pubmed:year |
2005
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pubmed:articleTitle |
Long-term results of hybrid therapy in patients with atrial fibrillation who develop atrial flutter during flecainide infusion.
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pubmed:affiliation |
Laboratorio di Elettrofisiologia, Villa Maria Cecilia Hospital, Cotignola (RA), Italy.
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pubmed:publicationType |
Journal Article
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