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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2005-1-28
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pubmed:abstractText |
Serum samples from people exposed to sheep at a research facility were evaluated by a commercial laboratory and resulted in an overall Coxiella burnetii seroprevalence of 75%. We interviewed individuals to determine exposure history and compatible illness, and retested their sera. Analysis indicated that the commercial laboratory was misinterpreting its results; when corrected, the seroprevalence dropped to 27%. Test kits of the brand used by the commercial laboratory gave equivalent results to the in-house CDC assay when tested in parallel at CDC. Upon final analysis, only the attending veterinarian was confirmed as a Q fever case. This event resulted in increased risk reduction protocols at the research facility and improved public health communication among health authorities. This pseudoepidemic resulted from a lapse in laboratory quality control for testing. Similar errors can be avoided through standardization and improved review of laboratory procedures.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1530-3667
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
343-350
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:15682517-Animals,
pubmed-meshheading:15682517-Antibodies, Bacterial,
pubmed-meshheading:15682517-Centers for Disease Control and Prevention (U.S.),
pubmed-meshheading:15682517-Clinical Laboratory Techniques,
pubmed-meshheading:15682517-Coxiella burnetii,
pubmed-meshheading:15682517-Disease Outbreaks,
pubmed-meshheading:15682517-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:15682517-Florida,
pubmed-meshheading:15682517-Humans,
pubmed-meshheading:15682517-Laboratories,
pubmed-meshheading:15682517-Q Fever,
pubmed-meshheading:15682517-Quality Control,
pubmed-meshheading:15682517-Reproducibility of Results,
pubmed-meshheading:15682517-Sensitivity and Specificity,
pubmed-meshheading:15682517-Seroepidemiologic Studies,
pubmed-meshheading:15682517-Sheep,
pubmed-meshheading:15682517-Sheep Diseases,
pubmed-meshheading:15682517-United States
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pubmed:year |
2004
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pubmed:articleTitle |
Pseudoepidemic of Q fever at an animal research facility.
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pubmed:affiliation |
Florida Department of Health, Tallahassee, Florida, USA. lisa_conti@doh.state.fl.us
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pubmed:publicationType |
Journal Article
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