Linked Life Data

15682394

Source:http://linkedlifedata.com/resource/pubmed/id/15682394

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2005-2-3
pubmed:abstractText
The Dlx transcription factors have a central role in controlling the development of gamma-aminobutyric acid (GABA)-ergic neurons in the forebrain. However, little is known about how they control the properties of GABAergic neurons. One candidate is the Aristaless (Arx) homeobox gene, which lies genetically downstream of the fly Dlx gene (Distal-less, Dll). The expression of Arx in the mouse forebrain includes Dlx-expressing territories, such us the ventral thalamus, parts of the hypothalamus, and the ganglionic eminences and their derivatives in the subpallial telencephalon, and is expressed, as with the Dlx genes, in cortical GABAergic neurons. By using gain-of-function and loss-of-function assays in mouse and chicken embryos, we show that the Dlx genes have a conserved role in regulating the expression of Arx in the forebrain of vertebrates. Ectopic expression of Dlx genes with electroporation in brain slices from mouse embryos and in the neural tube of chick embryos shows that Dlx genes are sufficient to induce Arx ectopically. Moreover, we provide evidence that the Dlx genes exert a functionally relevant role in regulating Arx in vivo, as shown by the severe reduction in the expression of Arx in Dlx1/2 double-knockout mice. Therefore, our results suggest evolutionarily conserved functions of Dlx genes in regulating Arx expression between Drosophila and vertebrates.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0021-9967
pubmed:author
pubmed:copyrightInfo
Copyright 2005 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:day
14
pubmed:volume
483
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
292-303
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:15682394-Animals, pubmed-meshheading:15682394-Calcium-Binding Protein, Vitamin D-Dependent, pubmed-meshheading:15682394-Chick Embryo, pubmed-meshheading:15682394-Electroporation, pubmed-meshheading:15682394-Embryo, Mammalian, pubmed-meshheading:15682394-Gene Expression Regulation, Developmental, pubmed-meshheading:15682394-Glial Fibrillary Acidic Protein, pubmed-meshheading:15682394-Homeodomain Proteins, pubmed-meshheading:15682394-Immunohistochemistry, pubmed-meshheading:15682394-In Situ Hybridization, pubmed-meshheading:15682394-Mice, pubmed-meshheading:15682394-Mice, Inbred C57BL, pubmed-meshheading:15682394-Mice, Knockout, pubmed-meshheading:15682394-Molecular Sequence Data, pubmed-meshheading:15682394-Neurons, pubmed-meshheading:15682394-Prosencephalon, pubmed-meshheading:15682394-Transcription Factors
pubmed:year
2005
pubmed:articleTitle
The vertebrate ortholog of Aristaless is regulated by Dlx genes in the developing forebrain.
pubmed:affiliation
Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, San Francisco, California 94158-2611, USA.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't