Linked Life Data

15681080

Source:http://linkedlifedata.com/resource/pubmed/id/15681080

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2005-1-31
pubmed:abstractText
A mathematical model is developed to describe the transport phenomena of a water-soluble small molecular drug (caffeine) from highly swellable and dissoluble polyethylene oxide (PEO) cylindrical tablets. Several important aspects in drug release kinetics were taken into account simultaneously in this theoretical model: swelling of the hydrophilic matrix and water penetration, three-dimensional and concentration-dependent diffusion of drug and water, and polymer dissolution. The moving boundary conditions are explicitly derived, and the resulting coupled partial differential equations are solved numerically. In vitro study of swelling, dissolution behavior of PEOs with different molecular weights and drug release are also carried out. When compared with experimental results, this theoretical model agrees with the water uptake, dimensional change and polymer dissolution profiles very well for pure PEO tablets with two different molecular weights. Drug release profiles using this model are predicted with a very good agreement with experimental data at different initial loadings. The overall drug release process is found to be highly dependent on the matrix swelling, drug and water diffusion, polymer dissolution and initial dimensions of the tablets. Their influences on drug release kinetics from PEO with two different molecular weights are also investigated.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0168-3659
pubmed:author
pubmed:issnType
Print
pubmed:day
16
pubmed:volume
102
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
569-81
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Mathematical modeling and in vitro study of controlled drug release via a highly swellable and dissoluble polymer matrix: polyethylene oxide with high molecular weights.
pubmed:affiliation
Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, #04-01, Singapore 138669, Singapore.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't