Linked Life Data

15675180

Source:http://linkedlifedata.com/resource/pubmed/id/15675180

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2005-1-28
pubmed:abstractText
Markers of inflammation are predictive of cardiovascular events but their association with atherosclerotic burden remains poorly defined. We hypothesized that markers of inflammation, including C-reactive protein (CRP), white blood cell (WBC) count, and lipoprotein-associated phospholipase A2 (Lp-PLA2), would be associated with the ankle-brachial index (ABI), a marker of atherosclerotic burden. Subjects were 247 patients referred for lower extremity arterial evaluation to the non-invasive vascular laboratory excluding those with active infection or lower extremity revascularization within the previous year. ABI was measured at two sites in both legs and the lowest of four measurements was used in the analyses. CRP was measured by a high-sensitivity immunoturbidimetric assay and Lp-PLA2 was measured by ELISA. The mean patient age was 68+/-11 years, and 54% were men. Mean ABI was 0.84+/-0.31 and 49% had an ABI < 0.9. Age, hypertension, fasting plasma glucose, and 'ever' smoking were independently associated with the ABI. Spearman correlation coefficients of inflammatory markers with the ABI were: CRP (r = -0.15, p= 0.02), WBC count (r = -0.27, p = 0.001), and Lp-PLA2 (r = -0.09, p = 0.21). In a multiple regression model that included conventional risk factors and statin use, CRP and WBC count were no longer significantly associated with ABI, whereas Lp-PLA2 was a borderline-significant predictor of lower ABI (p = 0.05). These data indicate that CRP and WBC count are not independently associated with ABI, a marker of atherosclerotic burden in subjects referred for non-invasive lower extremity arterial evaluation. The association of Lp-PLA2 with ABI merits further study.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1358-863X
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
171-6
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:15675180-1-Alkyl-2-acetylglycerophosphocholine Esterase, pubmed-meshheading:15675180-Aged, pubmed-meshheading:15675180-Ankle, pubmed-meshheading:15675180-Atherosclerosis, pubmed-meshheading:15675180-Biological Markers, pubmed-meshheading:15675180-Blood Pressure, pubmed-meshheading:15675180-Brachial Artery, pubmed-meshheading:15675180-C-Reactive Protein, pubmed-meshheading:15675180-Cholesterol, HDL, pubmed-meshheading:15675180-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:15675180-Female, pubmed-meshheading:15675180-Humans, pubmed-meshheading:15675180-Inflammation Mediators, pubmed-meshheading:15675180-Leukocyte Count, pubmed-meshheading:15675180-Male, pubmed-meshheading:15675180-Middle Aged, pubmed-meshheading:15675180-Nephelometry and Turbidimetry, pubmed-meshheading:15675180-Phospholipases A, pubmed-meshheading:15675180-Phospholipases A2, pubmed-meshheading:15675180-Predictive Value of Tests, pubmed-meshheading:15675180-Risk Factors, pubmed-meshheading:15675180-Sex Factors, pubmed-meshheading:15675180-Smoking
pubmed:year
2004
pubmed:articleTitle
Relation of markers of inflammation (C-reactive protein, white blood cell count, and lipoprotein-associated phospholipase A2) to the ankle-brachial index.
pubmed:affiliation
Divisions of Cardiovascular Disease, Mayo Clinic and Foundation, Rochester, MN 55905, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't, Evaluation Studies