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rdf:type |
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lifeskim:mentions |
umls-concept:C0017398,
umls-concept:C0021390,
umls-concept:C0023745,
umls-concept:C0332120,
umls-concept:C0596609,
umls-concept:C1415835,
umls-concept:C1512888,
umls-concept:C1513822,
umls-concept:C1847691,
umls-concept:C1880171,
umls-concept:C1999230
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pubmed:issue |
1
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pubmed:dateCreated |
2005-1-27
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pubmed:abstractText |
The inflammatory bowel diseases (IBDs) Crohn's disease (CD) and ulcerative colitis are complex disorders with an important genetic determinant. One gene associated with CD has been identified: NOD2/CARD15. Two independent genome-wide scans found significant evidence (logarithm of odds [LOD] 3.6) and suggestive evidence (LOD 2.8) for linkage on locus 14q11-12, also known as the IBD4 locus. To further characterize this locus, we assessed gene-environment interaction (IBD4 x smoking) and phenotypic heterogeneity in a large cohort of IBD-affected sibling pairs as part of an ongoing international collaborative effort.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1078-0998
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pubmed:author |
pubmed-author:AnneseVitoV,
pubmed-author:BarmadaMichael MMM,
pubmed-author:BrantSteven RSR,
pubmed-author:CavanaughJuleen AJA,
pubmed-author:ChoJudy HJH,
pubmed-author:DuerrRichard HRH,
pubmed-author:HugotJean-PierreJP,
pubmed-author:IBD International Genetics Consortium,
pubmed-author:McGovernDermot PDP,
pubmed-author:Paavola-SakkiPaulinaP,
pubmed-author:PavliPP,
pubmed-author:PierikMarieM,
pubmed-author:Radford-SmithGraham LGL,
pubmed-author:SchreiberStephanS,
pubmed-author:SilverbergMark SMS,
pubmed-author:TaylorKent DKD,
pubmed-author:VlietinckRobertR,
pubmed-author:YangHuiyingH
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15674107-Adolescent,
pubmed-meshheading:15674107-Adult,
pubmed-meshheading:15674107-Age of Onset,
pubmed-meshheading:15674107-Chromosomes, Human, Pair 14,
pubmed-meshheading:15674107-Cohort Studies,
pubmed-meshheading:15674107-Environment,
pubmed-meshheading:15674107-Female,
pubmed-meshheading:15674107-Genetic Predisposition to Disease,
pubmed-meshheading:15674107-Genotype,
pubmed-meshheading:15674107-Humans,
pubmed-meshheading:15674107-Inflammatory Bowel Diseases,
pubmed-meshheading:15674107-Male,
pubmed-meshheading:15674107-Microsatellite Repeats,
pubmed-meshheading:15674107-Pedigree,
pubmed-meshheading:15674107-Quantitative Trait Loci,
pubmed-meshheading:15674107-Siblings,
pubmed-meshheading:15674107-Smoking
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pubmed:year |
2005
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pubmed:articleTitle |
The IBD international genetics consortium provides further evidence for linkage to IBD4 and shows gene-environment interaction.
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pubmed:affiliation |
Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium. Marieke.Pierik@uz.kuleuven.ac.be
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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