15673421

Source:http://linkedlifedata.com/resource/pubmed/id/15673421

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0018801, umls-concept:C0062534, umls-concept:C0205263, umls-concept:C0302600, umls-concept:C1292734, umls-concept:C1512772
pubmed:issue	1
pubmed:dateCreated	2005-1-27
pubmed:abstractText	Heart failure following myocardial infarction (MI) is a significant cause of morbidity and mortality and remains a difficult therapeutic challenge. Hepatocyte growth factor (HGF) is a potent angiogenic and anti-apoptotic protein whose receptor is upregulated following MI. This study was designed to investigate the ability of HGF to prevent heart failure in a rat model of experimental MI.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/HL69597
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8908809
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Angiogenesis Inducing Agents, http://linkedlifedata.com/resource/pubmed/chemical/Hepatocyte Growth Factor
pubmed:status	MEDLINE
pubmed:issn	0886-0440
pubmed:author	pubmed-author:BerryMark FMF, pubmed-author:BishLawrence TLT, pubmed-author:BurdickJeffreyJ, pubmed-author:GardnerTimothy JTJ, pubmed-author:JayasankarVasantV, pubmed-author:PirolliTimothy JTJ, pubmed-author:SweeneyH LeeHL, pubmed-author:WooY JosephYJ
pubmed:issnType	Print
pubmed:volume	20
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	93-101
pubmed:dateRevised	2007-11-15
pubmed:meshHeading	pubmed-meshheading:15673421-Adenoviridae, pubmed-meshheading:15673421-Angiogenesis Inducing Agents, pubmed-meshheading:15673421-Animals, pubmed-meshheading:15673421-Apoptosis, pubmed-meshheading:15673421-Blotting, Western, pubmed-meshheading:15673421-Gene Transfer Techniques, pubmed-meshheading:15673421-Genes, bcl-2, pubmed-meshheading:15673421-Genetic Vectors, pubmed-meshheading:15673421-Heart Failure, pubmed-meshheading:15673421-Hepatocyte Growth Factor, pubmed-meshheading:15673421-In Situ Nick-End Labeling, pubmed-meshheading:15673421-Male, pubmed-meshheading:15673421-Myocardial Infarction, pubmed-meshheading:15673421-Neovascularization, Physiologic, pubmed-meshheading:15673421-Rats, pubmed-meshheading:15673421-Rats, Inbred Lew, pubmed-meshheading:15673421-Treatment Outcome, pubmed-meshheading:15673421-Up-Regulation
pubmed:articleTitle	Induction of angiogenesis and inhibition of apoptosis by hepatocyte growth factor effectively treats postischemic heart failure.
pubmed:affiliation	Department of Cardiothoracic Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural