Linked Life Data

15672946

Source:http://linkedlifedata.com/resource/pubmed/id/15672946

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2005-1-27
pubmed:abstractText
Gastric carcinogenesis is a complex, multistep process, which may be influenced by many factors and is the second most common type of malignancy and the second most-common cause of mortality in the word. Interleukin-1 is up-regulated in the presence of Helicobacter pylori and is important for initiating and amplifying the inflamatory response to this infection. Recently interleukin-1 polymorphisms have been associated with the development of gastric adenocarcinoma. In this study we investigated the presence of H. pylori and host genotypes that are highly associated with gastric alterations. DNA samples were extracted and PCR-RFLP was utilized for genotyping IL-1B (-511) polymorphisms, PCR-VNTR was utilized for genotyping IL-1RN, and PCR-CTPP was utilized for genotyping IL-1B (-31), the presence of H. pylori was detected by the urease test. Our results indicate a correlation between H. pylori infection and the development of gastric cancer. We did not find an association between the presence of genotype T (thymine) in bases -511 and -31 and gastric adenocarcinoma. We also did not find any association between this polymorphism and specific type of tumor (diffuse type and intestinal type).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1591-8890
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
93-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Interleukin-1beta polymorphisms, Helicobacter pylori infection in individuals from Northern Brazil with gastric adenocarcinoma.
pubmed:affiliation
Faculdade de Medicina de Marília, Disciplinas de Genètica e de Biologia Molecular, Hemocentro - Faculdade de Medicina de Marília, FAMEMA, Rua Lourival Freire, no. 240, CEP 17519-050, Bairro Fragata, Marília, São Paulo, Brazil. lobogatti@yahoo.com.br
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't