Linked Life Data

15672555

Source:http://linkedlifedata.com/resource/pubmed/id/15672555

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2005-1-27
pubmed:abstractText
The GABA system is an active target for drugs to treat a variety of disorders and the availability of an indirect measure of central GABA activity would not only enhance psychiatric research, but also permit assessment of the pharmacodynamic effects of drugs designed to act on this system. The relationships between plasma baseline pre-drug GABA concentrations and cognitive impairments induced by an acute oral dose of lorazepam (0.5 and 1.0 mg) were investigated in 22 healthy elderly individuals. Partial correlations controlling for plasma lorazepam concentrations revealed no significant relationship between baseline plasma GABA levels and lorazepam-induced impairments on tests of cognitive functioning. Plasma GABA concentration does not appear to be a useful marker of susceptibility to benzodiazepine-induced cognitive toxicity in the elderly. Other approaches to estimating central GABA activity should be pursued.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0364-3190
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2311-5
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Baseline plasma GABA: its relationship to the adverse effects of acute lorazepam administration on cognition in the elderly.
pubmed:affiliation
Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA. Pomara@nki.rfmh.org
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial