Linked Life Data

15672537

Source:http://linkedlifedata.com/resource/pubmed/id/15672537

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4-5
pubmed:dateCreated
2005-1-26
pubmed:abstractText
Rapid accumulating evidence has suggested that the homeodomain transcription factors of the Nkx family play important roles in controlling vertebrate organ patterning and differentiation. In this study, we report the cloning, expression and regulation of a novel chicken homeobox gene, cNkx-6.2, whose expression is similar, but not identical, to that of mouse Nkx-6.2. The earliest expression of cNkx-6.2 was detected at the neural plate stage in the prospective midbrain and hindbrain regions. As the neural development proceeds, cNkx-6.2 expression was restricted in the ventral region of the entire neural axis except the forebrain region. At late stages of development, cNkx-6.2 expression is downregulated in the ventricular neuroepithelial cells, but subsequently upregulated in a sub-population of cells. Tissue recombination and explant culture experiments demonstrated that expression of cNkx-6.2 can be induced by the notochord signal and purified SHH protein, and repressed by BMP-4 and -7, indicating that the cNkx-6.2 expression can be influenced by both ventral and dorsal midline signals. Taken together, these studies have suggested two different roles for the cNkx-6.2 transcription factor: participating in the Shh-initiated ventral patterning during early CNS development and controlling cell fate specification and differentiation during late development.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1058-8388
pubmed:author
pubmed:issnType
Print
pubmed:volume
216
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
459-68
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Expression and regulation of the chicken Nkx-6.2 homeobox gene suggest its possible involvement in the ventral neural patterning and cell fate specification.
pubmed:affiliation
Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, Kentucky, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't