Linked Life Data

15671667

Source:http://linkedlifedata.com/resource/pubmed/id/15671667

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2005-1-26
pubmed:abstractText
Mouse embryonic stem (ES) cell self-renewal depends upon extrinsic signals from leukemia inhibitory factor (LIF) and bone morphogenetic protein (BMP). These molecules activate, respectively, the nuclear localization of the latent transcription factor STAT3 and the expression of Id genes. In contrast, the homeodomain proteins Oct4 and the recently identified Nanog are intrinsic factors required for maintenance of the undifferentiated state. When overexpressed, Nanog allows ES cells to self-renew in the absence of the otherwise obligatory LIF and BMP signals. However, the highest efficiency of ES cell self-renewal occurs when Nanog is overexpressed and cells are exposed to LIF. In contrast, when Oct4 is overexpressed, ES cells differentiate in a similar manner to the differentiation that occurs upon LIF withdrawal. These observations are brought together to provide a genetic model of ES cell self-renewal centered upon interactions between Oct4, STAT3 and Nanog.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1536-2302
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
386-91
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
The molecular basis of pluripotency in mouse embryonic stem cells.
pubmed:affiliation
MRC Centre Development in Stem Cell Biology, Institute for Stem Cell Research, University of Edinburgh, King's Buildings, West Mains Rd., Edinburgh EH9 3JQ, Scotland. ichambers@ed.ac.uk
pubmed:publicationType
Journal Article, Review