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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-1-26
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pubmed:abstractText |
Telomeres of tumor cells may be maintained by telomerase or by alternative lengthening of telomeres (ALT). The standard ALT assay requires Southern analysis of high molecular weight genomic DNA. We aimed to establish and validate an ALT assay suitable for archived paraffin-embedded tumors and to use it to examine the prevalence and clinical significance of ALT in various types of tumors that are often telomerase negative.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:ArbuckleSusan MSM,
pubmed-author:BonarS FionaSF,
pubmed-author:HannayJonathan AJA,
pubmed-author:HensonJeremy DJD,
pubmed-author:JellinekDavid ADA,
pubmed-author:LearoydDiana LDL,
pubmed-author:McCarthyStanley WSW,
pubmed-author:PollockRaphael ERE,
pubmed-author:ReddelRoger RRR,
pubmed-author:RobinsonBruce GBG,
pubmed-author:RobinsonRobert ARA,
pubmed-author:RoydsJanice AJA,
pubmed-author:StalleyPaul DPD,
pubmed-author:WhartonStephen BSB,
pubmed-author:YeagerThomas RTR,
pubmed-author:YooJinyoungJ,
pubmed-author:YuDihuaD
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
217-25
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15671549-Adult,
pubmed-meshheading:15671549-Aged,
pubmed-meshheading:15671549-Apoptosis,
pubmed-meshheading:15671549-Astrocytoma,
pubmed-meshheading:15671549-Blotting, Southern,
pubmed-meshheading:15671549-Cell Aging,
pubmed-meshheading:15671549-Cell Line, Tumor,
pubmed-meshheading:15671549-Cell Nucleus,
pubmed-meshheading:15671549-Child,
pubmed-meshheading:15671549-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:15671549-Humans,
pubmed-meshheading:15671549-In Situ Hybridization, Fluorescence,
pubmed-meshheading:15671549-Leukemia, Promyelocytic, Acute,
pubmed-meshheading:15671549-Microscopy, Fluorescence,
pubmed-meshheading:15671549-Middle Aged,
pubmed-meshheading:15671549-Osteosarcoma,
pubmed-meshheading:15671549-Sarcoma,
pubmed-meshheading:15671549-Telomerase,
pubmed-meshheading:15671549-Telomere,
pubmed-meshheading:15671549-Thyroid Neoplasms,
pubmed-meshheading:15671549-Time Factors
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pubmed:year |
2005
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pubmed:articleTitle |
A robust assay for alternative lengthening of telomeres in tumors shows the significance of alternative lengthening of telomeres in sarcomas and astrocytomas.
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pubmed:affiliation |
Children's Medical Research Institute, New South Wales, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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