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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-1-26
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pubmed:abstractText |
The cytochrome P450 2D6 (CYP2D6) enzyme metabolizes risperidone. CYP2D6 poor metabolizers have no CYP2D6 activity (7% of whites and 1%-2% of other races). This study tested whether the CYP2D6 poor metabolizer phenotype was associated with adverse drug reactions (ADRs) and discontinuation due to ADRs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0160-6689
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
15-27
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15669884-Adult,
pubmed-meshheading:15669884-Antipsychotic Agents,
pubmed-meshheading:15669884-Basal Ganglia Diseases,
pubmed-meshheading:15669884-Cytochrome P-450 CYP2D6,
pubmed-meshheading:15669884-Dose-Response Relationship, Drug,
pubmed-meshheading:15669884-Drug Therapy, Combination,
pubmed-meshheading:15669884-Female,
pubmed-meshheading:15669884-Genetic Variation,
pubmed-meshheading:15669884-Genotype,
pubmed-meshheading:15669884-Humans,
pubmed-meshheading:15669884-Logistic Models,
pubmed-meshheading:15669884-Male,
pubmed-meshheading:15669884-Mental Disorders,
pubmed-meshheading:15669884-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:15669884-Patient Dropouts,
pubmed-meshheading:15669884-Pharmacogenetics,
pubmed-meshheading:15669884-Phenotype,
pubmed-meshheading:15669884-Polymerase Chain Reaction,
pubmed-meshheading:15669884-Risperidone,
pubmed-meshheading:15669884-Schizophrenia
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pubmed:year |
2005
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pubmed:articleTitle |
The CYP2D6 poor metabolizer phenotype may be associated with risperidone adverse drug reactions and discontinuation.
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pubmed:affiliation |
University of Kentucky Mental Health Research Center at Eastern State Hospital, Lexington, KY 40508, USA. jdeleon@uky.edu
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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