Source:http://linkedlifedata.com/resource/pubmed/id/15668488
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2005-1-25
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| pubmed:abstractText |
Elevated levels of plasma insulin-like growth factor I (IGF-I) are a potential risk factor for several cancers, including colorectal cancer. Physiologic levels of plasma IGF-I vary greatly; this variation may be in part genetically determined. We identified two single nucleotide polymorphisms (SNP) in perfect linkage disequilibrium with each other and in partial linkage disequilibrium with a previously studied cytosine-adenine microsatellite [-969(CA)(n)]. We investigated one of the SNPs, -533T/C,and the 969(CA)(n) in relation to the risk of colorectal cancer in a case-control study nested within a cohort of Singapore Chinese (cases/controls = 290:873). The (CA)(21) allele, rather than the previously implicated (CA)(19) allele, was associated with a reduced risk of colorectal cancer (odds ratio for 21/21 versus all other genotypes, 0.48; 95% confidence interval, 0.28-0.84). For the -533C/T SNP, persons carrying one or more copies of the C allele had a decreased in risk of colorectal cancer compared with noncarriers (odds ratio for CC/CT versus TT, 0.58; 95% confidence interval, 0.41-0.82). This association was specific for colon, as opposed to rectal cancer and was modified by age. We also examined a functional insulin-like growth factor binding protein (IGFBP3) promoter SNP, -202 A/C, previously reported to predict serum IGFBP3 levels. Although we were able to confirm this genotype-phenotype association, the -202A/C IGFBP3 SNP was not significantly associated with colorectal cancer risk. In conclusion, we report a novel SNP in the IGF-I regulatory region that is associated with colorectal cancer risk.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
1055-9965
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
14
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
144-51
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:15668488-Alleles,
pubmed-meshheading:15668488-Case-Control Studies,
pubmed-meshheading:15668488-Chi-Square Distribution,
pubmed-meshheading:15668488-Child,
pubmed-meshheading:15668488-China,
pubmed-meshheading:15668488-Colorectal Neoplasms,
pubmed-meshheading:15668488-Female,
pubmed-meshheading:15668488-Gene Frequency,
pubmed-meshheading:15668488-Genetics, Population,
pubmed-meshheading:15668488-Genotype,
pubmed-meshheading:15668488-Haplotypes,
pubmed-meshheading:15668488-Humans,
pubmed-meshheading:15668488-Insulin-Like Growth Factor I,
pubmed-meshheading:15668488-Linkage Disequilibrium,
pubmed-meshheading:15668488-Microsatellite Repeats,
pubmed-meshheading:15668488-Phenotype,
pubmed-meshheading:15668488-Polymorphism, Single Nucleotide,
pubmed-meshheading:15668488-Promoter Regions, Genetic,
pubmed-meshheading:15668488-Prospective Studies,
pubmed-meshheading:15668488-Regression Analysis,
pubmed-meshheading:15668488-Risk Factors,
pubmed-meshheading:15668488-Singapore
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| pubmed:year |
2005
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| pubmed:articleTitle |
A new single nucleotide polymorphism in the insulin-like growth factor I regulatory region associates with colorectal cancer risk in singapore chinese.
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| pubmed:affiliation |
University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA 90089, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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