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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-1-25
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pubmed:abstractText |
Eight cellular homologs of the inhibitors-of-apoptosis proteins (IAP) have been identified in humans and of them, the X-linked IAP (XIAP) is the most potent. XIAP-associated factor 1 (XAF1) is a newly discovered XIAP-binding protein that negatively regulates the caspase-inhibiting activity of XIAP. It is either not expressed or present at extremely low levels in many cancer cell lines. The aims of the present study were: (i) to investigate the expression of XAF1 in human colorectal cancers (CRC) both in vitro and in vivo, and (ii) to evaluate the possibility of XAF1 as a new tumor marker.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1443-9611
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
10-4
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15667552-Aged,
pubmed-meshheading:15667552-Apoptosis,
pubmed-meshheading:15667552-Case-Control Studies,
pubmed-meshheading:15667552-Colonic Neoplasms,
pubmed-meshheading:15667552-Female,
pubmed-meshheading:15667552-Gene Expression Profiling,
pubmed-meshheading:15667552-Humans,
pubmed-meshheading:15667552-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:15667552-Male,
pubmed-meshheading:15667552-Middle Aged,
pubmed-meshheading:15667552-Neoplasm Proteins,
pubmed-meshheading:15667552-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15667552-Tumor Cells, Cultured,
pubmed-meshheading:15667552-Tumor Markers, Biological,
pubmed-meshheading:15667552-Zinc Fingers
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pubmed:year |
2005
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pubmed:articleTitle |
Low expression of XIAP-associated factor 1 in human colorectal cancers.
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pubmed:affiliation |
Department of Gastroenterology, Ruijin Hospital, Shanghai Second Medical University, Shanghai, China. mtla@etang.com
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pubmed:publicationType |
Journal Article
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