Source:http://linkedlifedata.com/resource/pubmed/id/15666965
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2005-1-25
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| pubmed:abstractText |
Chlorination by-products (CBPs) in drinking water have been associated with an increased risk of adverse pregnancy outcomes, including small for gestational age at term (term-SGA) and preterm delivery. Epidemiological evidence is weakened by a generally inaccurate exposure assessment, often at an ecological level. A case control study with incident cases was performed in nine Italian towns between October 1999 and September 2000. A total of 1,194 subjects were enrolled: 343 preterm births (26th-37th not completed week of pregnancy), 239 term-SGA (from 37th completed week, and weight less than the lowest 10th percentile) and 612 controls. Exposure was assessed both by applying a questionnaire on mothers' personal habits during pregnancy and by water sampling directly at mothers' homes. Levels of trihalomethanes (THMs) were low (median: 1.10 microg l(-1)), while chlorite and chlorate concentrations were relatively high (median: 216.5 microg l(-1) for chlorites and 76.5 microg l(-1) for chlorates). Preterm birth showed no association with CBPs, while term-SGA, when chlorite levels > or =200 microg l(-1) combined with low and high levels of inhalation exposure are considered, suggested a dose-response relationship (adjusted-Odds Ratios (ORs): 1.52, 95%CI: 0.91-2.54 and 1.70, 95%CI: 0.97-3.0, respectively). A weak association with high exposure levels of either THMs (> or =30 microg l(-1)), or chlorite or chlorate (> or =200 microg l(-1)) was also found (adjusted-OR: 1.38, 95%CI: 0.92-2.07). Chlorine dioxide treatment is widespread in Italy; therefore, chlorite levels should be regularly and carefully monitored and their potential effects on pregnancy further evaluated and better understood.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
1477-8920
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| pubmed:author |
pubmed-author:AggazzottiGabriellaG,
pubmed-author:BarboneFabioF,
pubmed-author:BattagliaMario AlbertoMA,
pubmed-author:BiasottiBarbaraB,
pubmed-author:Collaborative Group for the Study of Chlorinated Drinking Waters and...,
pubmed-author:FabianiLeilaL,
pubmed-author:FantuzziGuglielminaG,
pubmed-author:KanitzStefanoS,
pubmed-author:LeoniValerioV,
pubmed-author:RaveraGianbattistaG,
pubmed-author:RighiElenaE,
pubmed-author:SansebastianoGiulianoG,
pubmed-author:SciaccaSalvatoreS,
pubmed-author:TriassiMariaM
|
| pubmed:issnType |
Print
|
| pubmed:volume |
2
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
233-47
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| pubmed:dateRevised |
2009-9-18
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| pubmed:meshHeading |
pubmed-meshheading:15666965-Adult,
pubmed-meshheading:15666965-Case-Control Studies,
pubmed-meshheading:15666965-Chlorine Compounds,
pubmed-meshheading:15666965-Dose-Response Relationship, Drug,
pubmed-meshheading:15666965-Environmental Exposure,
pubmed-meshheading:15666965-Female,
pubmed-meshheading:15666965-Humans,
pubmed-meshheading:15666965-Infant, Low Birth Weight,
pubmed-meshheading:15666965-Infant, Newborn,
pubmed-meshheading:15666965-Inhalation Exposure,
pubmed-meshheading:15666965-Italy,
pubmed-meshheading:15666965-Male,
pubmed-meshheading:15666965-Odds Ratio,
pubmed-meshheading:15666965-Pregnancy,
pubmed-meshheading:15666965-Pregnancy Outcome,
pubmed-meshheading:15666965-Premature Birth,
pubmed-meshheading:15666965-Risk Assessment,
pubmed-meshheading:15666965-Trihalomethanes,
pubmed-meshheading:15666965-Water Purification
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Chlorination by-products (CBPs) in drinking water and adverse pregnancy outcomes in Italy.
|
| pubmed:affiliation |
Dipartimento di Scienze Igienistiche, Microbiologiche e Biostatistiche, Università degli Studi di Modena e Reggio Emilia, Via Campi 287. 41100 Modena, Italy. g.aggazzotti@unimore.it
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|