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pubmed-article:15666259pubmed:abstractTextA prospective study was undertaken to determine if gastric motility and emptying are altered by the ingestion of overdoses of tricyclic antidepressants, acetaminophen, opioid-acetaminophen mixtures, carbamazepine or phenytoin. Gastric scintigraphy was used to measure gastric emptying half-time and assess gastric motility in 104 patients at initial presentation and again at follow-up (n = 85). Patients were imaged for 5 hours after being given 20 MBq of 99mTc tin colloid to drink. Drug serum levels were measured on all patients at initial presentation and at follow-up. We observed markedly prolonged gastric emptying half-times and severe hypomotility at initial presentation compared with follow-up in the vast majority of patients, except for a small group of patients with phenytoin poisoning. Twelve patients had gastric emptying half-times of over 300 minutes, a further 14 had half-times of over 200 minutes and 21 others had half-times of over 120 minutes. Poisoning is associated with hypomotility and a marked delay in gastric emptying that could influence the clinical course and patient management. These abnormalities may not be due to a direct effect of the ingested drug and factors such as stress may play a role.lld:pubmed
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pubmed-article:15666259pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:15666259pubmed:articleTitleProlonged gastric emptying half-time and gastric hypomotility after drug overdose.lld:pubmed
pubmed-article:15666259pubmed:affiliationDepartment of Nuclear Medicine, Groote Schuur Hospital, Cape Town, South Africa. bruceka@emirates.net.aelld:pubmed
pubmed-article:15666259pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15666259pubmed:publicationTypeComparative Studylld:pubmed
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