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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2005-1-24
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pubmed:abstractText |
A prospective study was undertaken to determine if gastric motility and emptying are altered by the ingestion of overdoses of tricyclic antidepressants, acetaminophen, opioid-acetaminophen mixtures, carbamazepine or phenytoin. Gastric scintigraphy was used to measure gastric emptying half-time and assess gastric motility in 104 patients at initial presentation and again at follow-up (n = 85). Patients were imaged for 5 hours after being given 20 MBq of 99mTc tin colloid to drink. Drug serum levels were measured on all patients at initial presentation and at follow-up. We observed markedly prolonged gastric emptying half-times and severe hypomotility at initial presentation compared with follow-up in the vast majority of patients, except for a small group of patients with phenytoin poisoning. Twelve patients had gastric emptying half-times of over 300 minutes, a further 14 had half-times of over 200 minutes and 21 others had half-times of over 120 minutes. Poisoning is associated with hypomotility and a marked delay in gastric emptying that could influence the clinical course and patient management. These abnormalities may not be due to a direct effect of the ingested drug and factors such as stress may play a role.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetaminophen,
http://linkedlifedata.com/resource/pubmed/chemical/Analgesics, Non-Narcotic,
http://linkedlifedata.com/resource/pubmed/chemical/Analgesics, Opioid,
http://linkedlifedata.com/resource/pubmed/chemical/Anticonvulsants,
http://linkedlifedata.com/resource/pubmed/chemical/Antidepressive Agents, Tricyclic,
http://linkedlifedata.com/resource/pubmed/chemical/Carbamazepine,
http://linkedlifedata.com/resource/pubmed/chemical/Central Nervous System Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Colloids,
http://linkedlifedata.com/resource/pubmed/chemical/Phenytoin,
http://linkedlifedata.com/resource/pubmed/chemical/Radiopharmaceuticals,
http://linkedlifedata.com/resource/pubmed/chemical/Technetium Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Tin Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/technetium Tc 99m tin colloid
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0735-6757
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
548-54
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15666259-Acetaminophen,
pubmed-meshheading:15666259-Adolescent,
pubmed-meshheading:15666259-Adult,
pubmed-meshheading:15666259-Aged,
pubmed-meshheading:15666259-Analgesics, Non-Narcotic,
pubmed-meshheading:15666259-Analgesics, Opioid,
pubmed-meshheading:15666259-Anticonvulsants,
pubmed-meshheading:15666259-Antidepressive Agents, Tricyclic,
pubmed-meshheading:15666259-Carbamazepine,
pubmed-meshheading:15666259-Central Nervous System Agents,
pubmed-meshheading:15666259-Colloids,
pubmed-meshheading:15666259-Female,
pubmed-meshheading:15666259-Follow-Up Studies,
pubmed-meshheading:15666259-Gastric Emptying,
pubmed-meshheading:15666259-Gastrointestinal Motility,
pubmed-meshheading:15666259-Humans,
pubmed-meshheading:15666259-Male,
pubmed-meshheading:15666259-Middle Aged,
pubmed-meshheading:15666259-Overdose,
pubmed-meshheading:15666259-Phenytoin,
pubmed-meshheading:15666259-Prospective Studies,
pubmed-meshheading:15666259-Radiopharmaceuticals,
pubmed-meshheading:15666259-Stomach,
pubmed-meshheading:15666259-Technetium Compounds,
pubmed-meshheading:15666259-Tin Compounds
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pubmed:year |
2004
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pubmed:articleTitle |
Prolonged gastric emptying half-time and gastric hypomotility after drug overdose.
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pubmed:affiliation |
Department of Nuclear Medicine, Groote Schuur Hospital, Cape Town, South Africa. bruceka@emirates.net.ae
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pubmed:publicationType |
Journal Article,
Comparative Study
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