Source:http://linkedlifedata.com/resource/pubmed/id/15665993
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2005-1-24
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pubmed:abstractText |
The anti-inflammatory effects of long-term ethanol intoxication were determined during ethanol treatment and withdrawal on the basis of neutrophil and eosinophil migration, hind paw edema and mast cell degranulation. Male Wistar rats (180-200 g, around 2 months of age) were exposed to increasing concentrations of ethanol vapor over a 10-day period. One group was evaluated immediately after exposure (treated group - intoxicated), and another was studied 7 h later (withdrawal group). Ethanol inhalation treatment significantly inhibited carrageenan--(62% for the intoxicated group, N = 5, and 35% for the withdrawal group, N = 6) and dextran-induced paw edema (32% for intoxicated rats and 26% for withdrawal rats, N = 5 per group). Ethanol inhalation significantly reduced carrageenan-induced neutrophil migration (95% for intoxicated rats and 41% for withdrawn rats, N = 6 per group) into a subcutaneous 6-day-old air pouch, and Sephadex-induced eosinophil migration to the rat peritoneal cavity (100% for intoxicated rats and 64% for withdrawn rats, N = 6 per group). A significant decrease of mast cell degranulation was also demonstrated (control, 82%; intoxicated, 49%; withdrawn, 51%, N = 6, 6 and 8, respectively). Total leukocyte and neutrophil counts in venous blood increased significantly during the 10 days of ethanol inhalation (leukocytes, 13, 27 and 40%; neutrophils, 42, 238 and 252%, respectively, on days 5, 9 and 10, N = 7, 6 and 6). The cell counts decreased during withdrawal, but were still significantly elevated (leukocytes, 10%; neutrophils, 246%, N = 6). These findings indicate that both the cellular and vascular components of the inflammatory response are compromised by long-term ethanol intoxication and remain reduced during the withdrawal period.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0100-879X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
81-9
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pubmed:meshHeading |
pubmed-meshheading:15665993-Alcoholic Intoxication,
pubmed-meshheading:15665993-Animals,
pubmed-meshheading:15665993-Carrageenan,
pubmed-meshheading:15665993-Cell Degranulation,
pubmed-meshheading:15665993-Cell Movement,
pubmed-meshheading:15665993-Dextrans,
pubmed-meshheading:15665993-Disease Models, Animal,
pubmed-meshheading:15665993-Edema,
pubmed-meshheading:15665993-Ethanol,
pubmed-meshheading:15665993-Inflammation,
pubmed-meshheading:15665993-Leukocyte Count,
pubmed-meshheading:15665993-Male,
pubmed-meshheading:15665993-Mast Cells,
pubmed-meshheading:15665993-Neutrophils,
pubmed-meshheading:15665993-Rats,
pubmed-meshheading:15665993-Rats, Wistar,
pubmed-meshheading:15665993-Time Factors
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pubmed:year |
2005
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pubmed:articleTitle |
Long-term ethanol intoxication reduces inflammatory responses in rats.
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pubmed:affiliation |
Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
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pubmed:publicationType |
Journal Article
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