|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0007587,
umls-concept:C0011155,
umls-concept:C0017639,
umls-concept:C0033308,
umls-concept:C0034693,
umls-concept:C0162429,
umls-concept:C0205245,
umls-concept:C0376202,
umls-concept:C0392756,
umls-concept:C0815278,
umls-concept:C0876926
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2005-1-24
|
|
pubmed:abstractText |
This report compares the effects of progesterone and its metabolite, allopregnanolone, on the early injury cascade (apoptosis) and long-term functional deficits after TBI. Progesterone (16 mg/kg) or allopregnanolone (4, 8, or 16 mg/kg) were injected at 1 h, 6 h, and then for 5 consecutive days after bilateral contusions of the frontal cortex in adult male rats. Within one day after injury, progesterone and allopregnanolone reduced both the expression of pro-apoptotic proteins caspase-3 and Bax, and apoptotic DNA fragmentation. Progesterone and allopregnanolone also reduced the size of glial fibrillary acid protein (GFAP)-positive astrocytes at the lesion site 24 h after injury. Compared to sham-operated controls at 19 days after injury, injured rats given either progesterone or any of three doses of allopregnanolone had equivalent numbers of ChAT-positive cells in the nucleus basalis magnocellularis. At 19 days post-injury, rats given progesterone or allopregnanolone (8 mg/kg) showed improved performance in a spatial learning task compared to injured rats given only the vehicle. These results provide evidence of the anti-apoptotic and anti-astrogliotic effects of progesterone and allopregnanolone and help to explain why better cognitive performance is observed after injury when animals are given either neurosteroid.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bax protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Casp3 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Neuroprotective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Pregnanolone,
http://linkedlifedata.com/resource/pubmed/chemical/Progesterone,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/bcl-2-Associated X Protein
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0897-7151
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
22
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
106-18
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:15665606-Animals,
pubmed-meshheading:15665606-Apoptosis,
pubmed-meshheading:15665606-Astrocytes,
pubmed-meshheading:15665606-Brain Injuries,
pubmed-meshheading:15665606-Caspase 3,
pubmed-meshheading:15665606-Caspases,
pubmed-meshheading:15665606-DNA Fragmentation,
pubmed-meshheading:15665606-Male,
pubmed-meshheading:15665606-Maze Learning,
pubmed-meshheading:15665606-Neurons,
pubmed-meshheading:15665606-Neuroprotective Agents,
pubmed-meshheading:15665606-Pregnanolone,
pubmed-meshheading:15665606-Progesterone,
pubmed-meshheading:15665606-Protein-Serine-Threonine Kinases,
pubmed-meshheading:15665606-Proto-Oncogene Proteins,
pubmed-meshheading:15665606-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:15665606-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:15665606-Rats,
pubmed-meshheading:15665606-Rats, Sprague-Dawley,
pubmed-meshheading:15665606-Time Factors,
pubmed-meshheading:15665606-bcl-2-Associated X Protein
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
The neurosteroids progesterone and allopregnanolone reduce cell death, gliosis, and functional deficits after traumatic brain injury in rats.
|
|
pubmed:affiliation |
Department of Emergency Medicine, Brain Research Laboratory, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
