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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2005-1-24
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pubmed:abstractText |
Proof of concept experiments have shown that tissue factor/factor VIIa inhibitors have antithrombotic activity without enhancing bleeding propensity. Starting from lead compounds generated by a biased combinatorial approach, phenylglycine amide tissue factor/factor VIIa inhibitors with low nanomolar affinity and good selectivity against other serine proteases of the coagulation cascade were designed, using the guidance of X-ray structural analysis and molecular modelling.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
817-22
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pubmed:meshHeading |
pubmed-meshheading:15664864-Drug Design,
pubmed-meshheading:15664864-Factor VIIa,
pubmed-meshheading:15664864-Fibrinolytic Agents,
pubmed-meshheading:15664864-Glycine,
pubmed-meshheading:15664864-Humans,
pubmed-meshheading:15664864-Kinetics,
pubmed-meshheading:15664864-Models, Molecular,
pubmed-meshheading:15664864-Molecular Structure,
pubmed-meshheading:15664864-Serine Proteinase Inhibitors,
pubmed-meshheading:15664864-Structure-Activity Relationship,
pubmed-meshheading:15664864-Thromboplastin
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pubmed:year |
2005
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pubmed:articleTitle |
Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors.
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pubmed:affiliation |
F. Hoffmann-La Roche Ltd, CH-4070 Basel, Switzerland. katrin.groebke_zbinden@roche.com
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pubmed:publicationType |
Journal Article
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