pubmed:abstractText |
Coupling reaction of 2-beta-C-methyl-1,2,3,4-tetra-O-benzoyl-d-ribofuranose with 4-amino-6-bromo-5-cyanopyrrolo[2,3-d]pyrimidine, followed by debromination and debenzoylation, gave the 2'-beta-C-methyl toyocamycin in high yield. Based on this result, a series of 2'-beta-C-methyl-4-substituted toyocamycin and sangivamycin analogues were synthesized for biological screening as potential inhibitors of HCV RNA replication.
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pubmed:affiliation |
Valeant Pharmaceuticals, Inc., 3300 Hyland Avenue, Costa Mesa, CA 92626, USA. yding@icnpharm.com
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