Linked Life Data

15664727

Source:http://linkedlifedata.com/resource/pubmed/id/15664727

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2005-1-24
pubmed:abstractText
The p53 tumor suppressor gene enhances longevity by inhibiting cancer development. However, Van Heemst et al. in this issue show that polymorphisms in the p53 gene may affect longevity in unexpected ways. A meta-analysis indicates that individuals homozygous for the p53 codon 72 Pro allele instead of the more prevalent Arg allele have a modest increase in cancer incidence. This difference in cancer suspectibility is consistent with molecular studies showing that the p53 Pro polymorphic variant is a less robust anti-proliferative molecule than its Arg counterpart. The most surprising result was obtained in a prospective study of individuals age 85 or older. Despite having a 2.5-fold increased cancer incidence, the p53 codon 72 Pro/Pro individuals exhibited a significant 41% enhanced survival compared to codon 72 Arg/Pro and Arg/Arg individuals. These paradoxical findings suggest that p53 may enhance survival through most of our life span, but may actively suppress longevity during old age. The mechanisms for such duplicity remain unclear, but insights from p53 mutant mouse models may help to sort out the mystery.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0531-5565
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7-9
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:articleTitle
p53: guardian AND suppressor of longevity?
pubmed:affiliation
Department of Molecular Virology and Microbiology and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA. larryd@bcm.tmc.edu
pubmed:publicationType
Journal Article, Comment, Review