Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2005-1-24
pubmed:abstractText
This study was to investigate the expression of Cdk inhibitors p27kip1 and p57kip2 during the development of mouse placenta and during the steroid-treated culture of human choriocarcinoma JEG-3 cells. The p27kip1 mRNA in mouse placenta was highly expressed in 18 days p.c. than that in other groups. But, p57kip2 mRNA expression was high in 12, 14, and 16 days p.c., then decreased in 18 days p.c. The p27kip1 protein expression pattern was similar to mRNA. But, p57kip2 expression was higher in 14 days p.c. than that in other groups. The p27kip1 protein in mouse placenta was gradually increased in labyrinth zone from 12 days to 18 days p.c. However, p57kip2 protein was slightly decreased in labyrinth zone from 12 days to 18 days p.c. These reverse patterns of p27kip1 and p57kip2 expression were also shown in decidua and spongiotrophoblast. The p27kip1 mRNA expression was very low in human choriocarcinoma JEG-3 cells with estradiol concentration-independent manner. In 5 and 50 ng DEX-treated groups, p27kip1 mRNA was dramatically increased in comparison with control groups. The p57kip2 mRNA was not detected in JEG-3 cells. This result shows that p27kip1 may play a role in late period of mouse placental development and p57kip2 may play a role in middle period of mouse placental development, and that p27kip1 may play a role in growth inhibition of human choriocarcinoma cells and could be up-regulated by DEX in human choriocarcinoma.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/CDKN1C protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Cdkn1b protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Cdkn1c protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor..., http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor..., http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers, http://linkedlifedata.com/resource/pubmed/chemical/Dexamethasone, http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0143-4004
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
73-80
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed-meshheading:15664414-Animals, pubmed-meshheading:15664414-Blotting, Western, pubmed-meshheading:15664414-Cell Cycle Proteins, pubmed-meshheading:15664414-Cell Line, Tumor, pubmed-meshheading:15664414-Choriocarcinoma, pubmed-meshheading:15664414-Cyclin-Dependent Kinase Inhibitor p27, pubmed-meshheading:15664414-Cyclin-Dependent Kinase Inhibitor p57, pubmed-meshheading:15664414-DNA Primers, pubmed-meshheading:15664414-Dexamethasone, pubmed-meshheading:15664414-Enzyme Inhibitors, pubmed-meshheading:15664414-Female, pubmed-meshheading:15664414-Gene Expression, pubmed-meshheading:15664414-Gestational Age, pubmed-meshheading:15664414-Humans, pubmed-meshheading:15664414-Immunohistochemistry, pubmed-meshheading:15664414-Mice, pubmed-meshheading:15664414-Mice, Inbred ICR, pubmed-meshheading:15664414-Nuclear Proteins, pubmed-meshheading:15664414-Placenta, pubmed-meshheading:15664414-Pregnancy, pubmed-meshheading:15664414-RNA, Messenger, pubmed-meshheading:15664414-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:15664414-Tumor Suppressor Proteins
pubmed:year
2005
pubmed:articleTitle
The expression of Cdk inhibitors p27kip1 and p57kip2 in mouse placenta and human choriocarcinoma JEG-3 cells.
pubmed:affiliation
Department of Obstetrics & Gynecology, Konyang University Hospital, Daejeon 302-241, Republic of Korea. stkim@kyuh.co.kr
pubmed:publicationType
Journal Article