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rdf:type |
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lifeskim:mentions |
umls-concept:C0011847,
umls-concept:C0018787,
umls-concept:C0035820,
umls-concept:C0040690,
umls-concept:C0146337,
umls-concept:C0331858,
umls-concept:C0333562,
umls-concept:C0599946,
umls-concept:C1517004,
umls-concept:C1704640,
umls-concept:C1706515
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pubmed:issue |
3
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pubmed:dateCreated |
2005-1-24
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pubmed:abstractText |
The pathological accumulation of extracellular matrix is a characteristic feature of diabetic cardiomyopathy that is directly related to a loss of function. Tranilast (n-[3,4-anthranilic acid), used for the treatment of fibrotic skin diseases, has also been shown to inhibit transforming growth factor-beta (TGF-beta)-induced matrix production in kidney epithelial cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anthranilic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Madh2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Smad2 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Tgfb1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta1,
http://linkedlifedata.com/resource/pubmed/chemical/tranilast
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0008-6363
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
694-701
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15664396-Animals,
pubmed-meshheading:15664396-Anthranilic Acids,
pubmed-meshheading:15664396-Collagen,
pubmed-meshheading:15664396-DNA-Binding Proteins,
pubmed-meshheading:15664396-Diabetes Mellitus, Experimental,
pubmed-meshheading:15664396-Diabetic Angiopathies,
pubmed-meshheading:15664396-Extracellular Matrix,
pubmed-meshheading:15664396-Female,
pubmed-meshheading:15664396-Fibroblasts,
pubmed-meshheading:15664396-Fibrosis,
pubmed-meshheading:15664396-Heart,
pubmed-meshheading:15664396-Myocardium,
pubmed-meshheading:15664396-Phosphorylation,
pubmed-meshheading:15664396-Rats,
pubmed-meshheading:15664396-Smad2 Protein,
pubmed-meshheading:15664396-Trans-Activators,
pubmed-meshheading:15664396-Transforming Growth Factor beta,
pubmed-meshheading:15664396-Transforming Growth Factor beta1
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pubmed:year |
2005
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pubmed:articleTitle |
Tranilast attenuates cardiac matrix deposition in experimental diabetes: role of transforming growth factor-beta.
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pubmed:affiliation |
University of Melbourne, Department of Medicine, St. Vincent's Hospital, Victoria, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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