Source:http://linkedlifedata.com/resource/pubmed/id/15663749
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rdf:type | |
lifeskim:mentions |
umls-concept:C0002085,
umls-concept:C0012655,
umls-concept:C0021760,
umls-concept:C0205216,
umls-concept:C0229671,
umls-concept:C0266929,
umls-concept:C0332281,
umls-concept:C0392756,
umls-concept:C0441889,
umls-concept:C0681850,
umls-concept:C1550501,
umls-concept:C1556094,
umls-concept:C1706203,
umls-concept:C2349001,
umls-concept:C2697811
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pubmed:issue |
1
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pubmed:dateCreated |
2005-1-24
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pubmed:abstractText |
We investigated whether interleukin-6 (IL-6) gene polymorphisms could be associated with chronic periodontitis (CP) and serum IL-6 level. One hundred and twelve CP and 77 non-CP Japanese subjects were analyzed for IL-6 -597 (G/A), -572 (C/G), -373 (A(n)T(m)), -190 (C/T), and -174 (G/C) polymorphisms. We could only detect -572 and -373 polymorphisms and found that the frequency and carriage rate of the -373 A9T11 allele were significantly higher in non-CP subjects. Enzyme-linked immunosorbent assay confirmed that the -572 and -373 G[A9T11] haplotypes were associated with lower serum IL-6 level. These findings suggest that IL-6 -373 A9T11 allele could be associated with reduced susceptibility to CP among Japanese subjects and decreased serum IL-6 level.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0001-2815
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
110-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15663749-Alleles,
pubmed-meshheading:15663749-Chronic Disease,
pubmed-meshheading:15663749-Genetic Markers,
pubmed-meshheading:15663749-Genetic Predisposition to Disease,
pubmed-meshheading:15663749-Genotype,
pubmed-meshheading:15663749-Humans,
pubmed-meshheading:15663749-Interleukin-6,
pubmed-meshheading:15663749-Japan,
pubmed-meshheading:15663749-Periodontitis
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pubmed:year |
2005
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pubmed:articleTitle |
Interleukin-6 (IL-6)--373 A9T11 allele is associated with reduced susceptibility to chronic periodontitis in Japanese subjects and decreased serum IL-6 level.
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pubmed:affiliation |
Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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