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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2005-1-21
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pubmed:abstractText |
We investigated the peripheral blood gene expression profile of interferon induced transmembrane protein 1 (IFITM1) in sixty chronic myeloid leukemia (CML) patients classified according to new prognostic score (NPS). IFITM1 is a component of a multimeric complex involved in the trunsduction of antiproliferative and cell adhesion signals. Expression level of IFITM1 was found significantly different between the high- and low-risk groups (P = 9.7976 x 10(-11)) by real-time reverse transcription polymerase chain reaction (RT-PCR). Higher IFITM1 expression correlated with improved survival (P = 0.01). These results indicate that IFITM1 expression profiling could be used for molecular classification of CML, which may also predict survival.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0145-2126
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pubmed:author |
pubmed-author:AkanHamdiH,
pubmed-author:AkyerliCemaliye BoyluCB,
pubmed-author:BeksacMeralM,
pubmed-author:DalvaKlaraK,
pubmed-author:FrevelMathiasM,
pubmed-author:GürmanGünhanG,
pubmed-author:HolkoMichelleM,
pubmed-author:IlhanOsmanO,
pubmed-author:OzçelikTayfunT,
pubmed-author:OzbekU?urU,
pubmed-author:OzcanMuhitM,
pubmed-author:OzetGülsümG,
pubmed-author:SoydanEnderE,
pubmed-author:WilliamsBryan R GBR
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pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
283-6
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:15661263-Adult,
pubmed-meshheading:15661263-Aged,
pubmed-meshheading:15661263-Antigens, Differentiation,
pubmed-meshheading:15661263-Female,
pubmed-meshheading:15661263-Humans,
pubmed-meshheading:15661263-Leukemia, Myelogenous, Chronic, BCR-ABL Positive,
pubmed-meshheading:15661263-Male,
pubmed-meshheading:15661263-Membrane Proteins,
pubmed-meshheading:15661263-Middle Aged,
pubmed-meshheading:15661263-Prognosis,
pubmed-meshheading:15661263-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15661263-Survival Analysis,
pubmed-meshheading:15661263-Tumor Markers, Biological
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pubmed:year |
2005
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pubmed:articleTitle |
Expression of IFITM1 in chronic myeloid leukemia patients.
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pubmed:affiliation |
Department of Molecular Biology and Genetics, Bilkent University, Bilkent, 06800 Ankara, Turkey.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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