| pubmed-article:15661046 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15661046 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:15661046 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:15661046 | lifeskim:mentions | umls-concept:C0056912 | lld:lifeskim |
| pubmed-article:15661046 | lifeskim:mentions | umls-concept:C0439677 | lld:lifeskim |
| pubmed-article:15661046 | lifeskim:mentions | umls-concept:C0205251 | lld:lifeskim |
| pubmed-article:15661046 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15661046 | pubmed:dateCreated | 2005-1-21 | lld:pubmed |
| pubmed-article:15661046 | pubmed:abstractText | Dendritic cells (DC) are professional APC that have an extraordinary capacity to prime naive T cells. It has been reported that human DC subsets express distinct toll-like receptor (TLR), which influences their function. In mice, we observed that plasmocytoid DC (pDC) express a higher level of TLR9 compared with myeloid DC (mDC) cultured with GM-CSF. However, we demonstrated that stimulation with IFN-gamma is capable of upregulating TLR9 expression in mDC to a level comparable with expression in pDC. Consistent with this observation, IL-12 p40 and IL-6 mRNA expression and IL-12 p70 secretion in response to CpG-oligodeoxynucleotides are enhanced in mDC pretreated with IFN-gamma compared with untreated cells. Therefore, TLR-mediated responses of DC subsets may be influenced not only by signals delivered by pathogens but also by regulatory signals from cytokines such as IFN-gamma. | lld:pubmed |
| pubmed-article:15661046 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15661046 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15661046 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15661046 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15661046 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15661046 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15661046 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15661046 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15661046 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15661046 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15661046 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15661046 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15661046 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15661046 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15661046 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15661046 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15661046 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:15661046 | pubmed:issn | 0818-9641 | lld:pubmed |
| pubmed-article:15661046 | pubmed:author | pubmed-author:NagataToshiT | lld:pubmed |
| pubmed-article:15661046 | pubmed:author | pubmed-author:AoshiTaikiT | lld:pubmed |
| pubmed-article:15661046 | pubmed:author | pubmed-author:UchijimaMasat... | lld:pubmed |
| pubmed-article:15661046 | pubmed:author | pubmed-author:KoideYukioY | lld:pubmed |
| pubmed-article:15661046 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15661046 | pubmed:volume | 83 | lld:pubmed |
| pubmed-article:15661046 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15661046 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15661046 | pubmed:pagination | 92-5 | lld:pubmed |
| pubmed-article:15661046 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:15661046 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15661046 | pubmed:articleTitle | IFN-gamma overcomes low responsiveness of myeloid dendritic cells to CpG DNA. | lld:pubmed |
| pubmed-article:15661046 | pubmed:affiliation | Department of Microbiology and Immunology, Hamamatsu University School of Medicine, Hamamatsu, Japan. | lld:pubmed |
| pubmed-article:15661046 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15661046 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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