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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-1-21
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pubmed:abstractText |
Dendritic cells (DC) are professional APC that have an extraordinary capacity to prime naive T cells. It has been reported that human DC subsets express distinct toll-like receptor (TLR), which influences their function. In mice, we observed that plasmocytoid DC (pDC) express a higher level of TLR9 compared with myeloid DC (mDC) cultured with GM-CSF. However, we demonstrated that stimulation with IFN-gamma is capable of upregulating TLR9 expression in mDC to a level comparable with expression in pDC. Consistent with this observation, IL-12 p40 and IL-6 mRNA expression and IL-12 p70 secretion in response to CpG-oligodeoxynucleotides are enhanced in mDC pretreated with IFN-gamma compared with untreated cells. Therefore, TLR-mediated responses of DC subsets may be influenced not only by signals delivered by pathogens but also by regulatory signals from cytokines such as IFN-gamma.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-12 Subunit p40,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Oligodeoxyribonucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Subunits,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Tlr9 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 9
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0818-9641
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
92-5
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15661046-Animals,
pubmed-meshheading:15661046-Bone Marrow,
pubmed-meshheading:15661046-Cells, Cultured,
pubmed-meshheading:15661046-CpG Islands,
pubmed-meshheading:15661046-DNA, Bacterial,
pubmed-meshheading:15661046-DNA-Binding Proteins,
pubmed-meshheading:15661046-Dendritic Cells,
pubmed-meshheading:15661046-Female,
pubmed-meshheading:15661046-Immunity,
pubmed-meshheading:15661046-Interferon-gamma,
pubmed-meshheading:15661046-Interleukin-12,
pubmed-meshheading:15661046-Interleukin-12 Subunit p40,
pubmed-meshheading:15661046-Interleukin-6,
pubmed-meshheading:15661046-Mice,
pubmed-meshheading:15661046-Mice, Inbred BALB C,
pubmed-meshheading:15661046-Oligodeoxyribonucleotides,
pubmed-meshheading:15661046-Protein Subunits,
pubmed-meshheading:15661046-RNA, Messenger,
pubmed-meshheading:15661046-Receptors, Cell Surface,
pubmed-meshheading:15661046-Toll-Like Receptor 9,
pubmed-meshheading:15661046-Up-Regulation
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pubmed:year |
2005
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pubmed:articleTitle |
IFN-gamma overcomes low responsiveness of myeloid dendritic cells to CpG DNA.
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pubmed:affiliation |
Department of Microbiology and Immunology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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