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pubmed-article:15660373pubmed:abstractTextProtease-activated receptor-2 (PAR-2) is a G protein-coupled receptor that is activated by trypsin. Recent studies have suggested that PAR-2 activity correlates with inflammatory processes and cell proliferation and that PAR-2 activation in non-neoplastic cells induces expression of cyclooxygenase-2 (COX-2). In the present study, we examined whether PAR-2 activation regulates cell proliferation and COX-2 expression by pancreatic cancer cells.lld:pubmed
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pubmed-article:15660373pubmed:authorpubmed-author:MatsumotoTosh...lld:pubmed
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pubmed-article:15660373pubmed:dateRevised2005-11-17lld:pubmed
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pubmed-article:15660373pubmed:articleTitleProtease-activated receptor-2 regulates cell proliferation and enhances cyclooxygenase-2 mRNA expression in human pancreatic cancer cells.lld:pubmed
pubmed-article:15660373pubmed:affiliationDepartment of Surgery I, Oita University Faculty of Medicine, Oita, Japan. kazuyada@med.oita-u.ac.jplld:pubmed
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