|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2005-1-26
|
|
pubmed:abstractText |
Protease-activated receptor-2 (PAR-2) is a G protein-coupled receptor that is activated by trypsin. Recent studies have suggested that PAR-2 activity correlates with inflammatory processes and cell proliferation and that PAR-2 activation in non-neoplastic cells induces expression of cyclooxygenase-2 (COX-2). In the present study, we examined whether PAR-2 activation regulates cell proliferation and COX-2 expression by pancreatic cancer cells.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PTGS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, PAR-2
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0022-4790
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
(c) 2005 Wiley-Liss, Inc.
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
89
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
79-85
|
|
pubmed:dateRevised |
2005-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:15660373-Adenocarcinoma, Mucinous,
pubmed-meshheading:15660373-Adenoma,
pubmed-meshheading:15660373-Antibodies, Monoclonal,
pubmed-meshheading:15660373-Carcinoma, Pancreatic Ductal,
pubmed-meshheading:15660373-Carcinoma, Papillary,
pubmed-meshheading:15660373-Cell Line, Tumor,
pubmed-meshheading:15660373-Cell Proliferation,
pubmed-meshheading:15660373-Cyclooxygenase 2,
pubmed-meshheading:15660373-Humans,
pubmed-meshheading:15660373-Immunohistochemistry,
pubmed-meshheading:15660373-Membrane Proteins,
pubmed-meshheading:15660373-Pancreatic Neoplasms,
pubmed-meshheading:15660373-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:15660373-RNA, Messenger,
pubmed-meshheading:15660373-Receptor, PAR-2,
pubmed-meshheading:15660373-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15660373-Signal Transduction
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
Protease-activated receptor-2 regulates cell proliferation and enhances cyclooxygenase-2 mRNA expression in human pancreatic cancer cells.
|
|
pubmed:affiliation |
Department of Surgery I, Oita University Faculty of Medicine, Oita, Japan. kazuyada@med.oita-u.ac.jp
|
|
pubmed:publicationType |
Journal Article
|
