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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2005-1-20
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pubmed:abstractText |
We hypothesize that remodeling of the scleral extracellular matrix, involving collagen and proteoglycan synthesis and turnover, is a key process involved in ocular growth. Decreased axial elongation is observed following neonatal removal of the crystalline lens in a rhesus monkey model of congenital cataract. We wanted to determine changes in gene expression in the operated and companion eye following lensectomy, especially for extracellular matrix in the sclera.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1090-0535
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
13
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
36-49
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15660023-Animals,
pubmed-meshheading:15660023-Animals, Newborn,
pubmed-meshheading:15660023-Aphakia,
pubmed-meshheading:15660023-Extracellular Matrix,
pubmed-meshheading:15660023-Extracellular Matrix Proteins,
pubmed-meshheading:15660023-Eye,
pubmed-meshheading:15660023-Eye Proteins,
pubmed-meshheading:15660023-Gene Expression Profiling,
pubmed-meshheading:15660023-Gene Expression Regulation,
pubmed-meshheading:15660023-Lens, Crystalline,
pubmed-meshheading:15660023-Macaca mulatta,
pubmed-meshheading:15660023-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:15660023-RNA,
pubmed-meshheading:15660023-RNA, Messenger,
pubmed-meshheading:15660023-Sclera,
pubmed-meshheading:15660023-Up-Regulation
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pubmed:year |
2005
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pubmed:articleTitle |
Neonatal aphakia retards ocular growth and alters scleral gene expression in rhesus monkeys.
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pubmed:affiliation |
Health Research Institute, Orlando Regional Healthcare, Orlando, FL 32806, USA. rtarnuzz@orhs.org
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
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