| pubmed-article:1565890 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1565890 | lifeskim:mentions | umls-concept:C0034493 | lld:lifeskim |
| pubmed-article:1565890 | lifeskim:mentions | umls-concept:C0006549 | lld:lifeskim |
| pubmed-article:1565890 | lifeskim:mentions | umls-concept:C2709248 | lld:lifeskim |
| pubmed-article:1565890 | lifeskim:mentions | umls-concept:C0231835 | lld:lifeskim |
| pubmed-article:1565890 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1565890 | pubmed:dateCreated | 1992-5-21 | lld:pubmed |
| pubmed-article:1565890 | pubmed:abstractText | The effects of phenylbiguanide (PBG) on phrenic nerve and pulmonary C-fibers were studied in anesthetized spontaneously breathing rabbits with unilateral vagotomy. Right atrial injections of PBG at low (10 micrograms/kg) and high (100 micrograms/kg) dose resulted in a shallow tachypnea and apneusis followed by tachypnea, respectively, and these effects were blocked by procaine treatment of the vagus nerve. Also, the injection of PBG (100 micrograms/kg) still evoked the rapid shallow breathing preceded by apneusis in carotid chemoreceptor-denervated animals. Vigorous stimulation of pulmonary C-fibers by PBG (100 micrograms/kg) coincided with apneusis and the response was followed by a more modest increase in activity associated with tachypnea. Administration of PBG (10 micrograms/kg) into the right atrium caused an increase in pulmonary C-fiber activity associated with tachypnea. However, a small dose of PBG injected into the aortic circulation had no effect on the C-fiber activity but did inhibit respiration. These results suggest that the stimulation of pulmonary C-fibers via PBG injection can produce both inspiratory apnea and tachypnea. | lld:pubmed |
| pubmed-article:1565890 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1565890 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1565890 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1565890 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1565890 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1565890 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1565890 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1565890 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:1565890 | pubmed:issn | 0034-5687 | lld:pubmed |
| pubmed-article:1565890 | pubmed:author | pubmed-author:ShimizuTT | lld:pubmed |
| pubmed-article:1565890 | pubmed:author | pubmed-author:YamasakiMM | lld:pubmed |
| pubmed-article:1565890 | pubmed:author | pubmed-author:KannoTT | lld:pubmed |
| pubmed-article:1565890 | pubmed:author | pubmed-author:MatsumotoSS | lld:pubmed |
| pubmed-article:1565890 | pubmed:author | pubmed-author:NagayamaTT | lld:pubmed |
| pubmed-article:1565890 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1565890 | pubmed:volume | 87 | lld:pubmed |
| pubmed-article:1565890 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1565890 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1565890 | pubmed:pagination | 165-81 | lld:pubmed |
| pubmed-article:1565890 | pubmed:dateRevised | 2009-11-11 | lld:pubmed |
| pubmed-article:1565890 | pubmed:meshHeading | pubmed-meshheading:1565890-... | lld:pubmed |
| pubmed-article:1565890 | pubmed:meshHeading | pubmed-meshheading:1565890-... | lld:pubmed |
| pubmed-article:1565890 | pubmed:meshHeading | pubmed-meshheading:1565890-... | lld:pubmed |
| pubmed-article:1565890 | pubmed:meshHeading | pubmed-meshheading:1565890-... | lld:pubmed |
| pubmed-article:1565890 | pubmed:meshHeading | pubmed-meshheading:1565890-... | lld:pubmed |
| pubmed-article:1565890 | pubmed:meshHeading | pubmed-meshheading:1565890-... | lld:pubmed |
| pubmed-article:1565890 | pubmed:meshHeading | pubmed-meshheading:1565890-... | lld:pubmed |
| pubmed-article:1565890 | pubmed:meshHeading | pubmed-meshheading:1565890-... | lld:pubmed |
| pubmed-article:1565890 | pubmed:meshHeading | pubmed-meshheading:1565890-... | lld:pubmed |
| pubmed-article:1565890 | pubmed:meshHeading | pubmed-meshheading:1565890-... | lld:pubmed |
| pubmed-article:1565890 | pubmed:meshHeading | pubmed-meshheading:1565890-... | lld:pubmed |
| pubmed-article:1565890 | pubmed:meshHeading | pubmed-meshheading:1565890-... | lld:pubmed |
| pubmed-article:1565890 | pubmed:meshHeading | pubmed-meshheading:1565890-... | lld:pubmed |
| pubmed-article:1565890 | pubmed:meshHeading | pubmed-meshheading:1565890-... | lld:pubmed |
| pubmed-article:1565890 | pubmed:meshHeading | pubmed-meshheading:1565890-... | lld:pubmed |
| pubmed-article:1565890 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1565890 | pubmed:articleTitle | Pulmonary C-fibers elicit both apneusis and tachypnea in the rabbit. | lld:pubmed |
| pubmed-article:1565890 | pubmed:affiliation | Department of Physiology, Fukushima Medical College, Japan. | lld:pubmed |
| pubmed-article:1565890 | pubmed:publicationType | Journal Article | lld:pubmed |
