rdf:type |
|
lifeskim:mentions |
umls-concept:C0015219,
umls-concept:C0016132,
umls-concept:C0025344,
umls-concept:C0205251,
umls-concept:C1325796,
umls-concept:C1514562,
umls-concept:C1519249,
umls-concept:C1561960,
umls-concept:C1615607,
umls-concept:C1825747,
umls-concept:C1880389,
umls-concept:C1883204,
umls-concept:C1883221,
umls-concept:C1948053,
umls-concept:C2076600,
umls-concept:C2347804
|
pubmed:issue |
1
|
pubmed:dateCreated |
1992-5-21
|
pubmed:abstractText |
This study used the nucleotide sequence coding for the HA1 domain of virus haemagglutinin to show that influenza A/Finland/158/91, which represents the H1N1 subtype viruses prevalent in Finland in 1990/91, was a direct descendant of a virus (A/NN/1605/88) isolated during the 1988/89 epidemic season in Japan. The elevated rate of 7.4 x 10(-3) nucleotide substitutions per site per year is discussed. The new branch of H1N1 subtype viruses is characterized by loss of a glycosylation site, which may affect subsequent antigenic drift.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:issn |
0923-2516
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
143
|
pubmed:geneSymbol |
HA1
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
11-6
|
pubmed:dateRevised |
2010-11-18
|
pubmed:meshHeading |
pubmed-meshheading:1565849-Amino Acid Sequence,
pubmed-meshheading:1565849-Base Sequence,
pubmed-meshheading:1565849-Biological Evolution,
pubmed-meshheading:1565849-Finland,
pubmed-meshheading:1565849-Hemagglutinins, Viral,
pubmed-meshheading:1565849-Influenza A Virus, H1N1 Subtype,
pubmed-meshheading:1565849-Influenza A virus,
pubmed-meshheading:1565849-Molecular Sequence Data,
pubmed-meshheading:1565849-Mutation
|
pubmed:articleTitle |
Evolution of influenza A(H1N1) viruses during a period of low antigenic drift in 1986-91: sequence of the HA1 domain of influenza A/Finland/158/91.
|
pubmed:affiliation |
National Public Health Institute (NPHI), Helsinki.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|