Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1992-5-15
pubmed:databankReference
pubmed:abstractText
The serotonin 1D (5-HT1D) receptor is a pharmacologically defined binding site and functional receptor site. Observed variations in the properties of 5-HT1D receptors in different tissues have led to the speculation that multiple receptor proteins with slightly different properties may exist. We report here the cloning, deduced amino acid sequences, pharmacological properties, and second-messenger coupling of a pair of human 5-HT1D receptor genes, which we have designated 5-HT1D alpha and 5-HT1D beta due to their strong similarities in sequence, pharmacological properties, and second-messenger coupling. Both genes are free of introns in their coding regions, are expressed in the human cerebral cortex, and can couple to inhibition of adenylate cyclase activity. The pharmacological binding properties of these two human receptors are very similar, and match closely the pharmacological properties of human, bovine, and guinea pig 5-HT1D sites. Both receptors exhibit high-affinity binding of sumatriptan, a new anti-migraine medication, and thus are candidates for the pharmacological site of action of this drug.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1565658-1652050, http://linkedlifedata.com/resource/pubmed/commentcorrection/1565658-1732716, http://linkedlifedata.com/resource/pubmed/commentcorrection/1565658-1758439, http://linkedlifedata.com/resource/pubmed/commentcorrection/1565658-1836757, http://linkedlifedata.com/resource/pubmed/commentcorrection/1565658-2078270, http://linkedlifedata.com/resource/pubmed/commentcorrection/1565658-2159630, http://linkedlifedata.com/resource/pubmed/commentcorrection/1565658-2172775, http://linkedlifedata.com/resource/pubmed/commentcorrection/1565658-2215849, http://linkedlifedata.com/resource/pubmed/commentcorrection/1565658-2255330, http://linkedlifedata.com/resource/pubmed/commentcorrection/1565658-2430334, http://linkedlifedata.com/resource/pubmed/commentcorrection/1565658-2541503, http://linkedlifedata.com/resource/pubmed/commentcorrection/1565658-2545459, http://linkedlifedata.com/resource/pubmed/commentcorrection/1565658-2545718, http://linkedlifedata.com/resource/pubmed/commentcorrection/1565658-2553192, http://linkedlifedata.com/resource/pubmed/commentcorrection/1565658-2665245, http://linkedlifedata.com/resource/pubmed/commentcorrection/1565658-271968, http://linkedlifedata.com/resource/pubmed/commentcorrection/1565658-2770889, http://linkedlifedata.com/resource/pubmed/commentcorrection/1565658-2797214, http://linkedlifedata.com/resource/pubmed/commentcorrection/1565658-2850055, http://linkedlifedata.com/resource/pubmed/commentcorrection/1565658-2951504, http://linkedlifedata.com/resource/pubmed/commentcorrection/1565658-3141589, http://linkedlifedata.com/resource/pubmed/commentcorrection/1565658-3371410, http://linkedlifedata.com/resource/pubmed/commentcorrection/1565658-4202581, http://linkedlifedata.com/resource/pubmed/commentcorrection/1565658-6312838
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
89
pubmed:geneSymbol
5-HT<down>1D&agr;</down>, 5-HT<down>1D&bgr;</down>
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3630-4
pubmed:dateRevised
2010-9-7
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta.
pubmed:affiliation
Synaptic Pharmaceutical Corporation, Paramus, NJ 07652.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't