rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
1
|
pubmed:dateCreated |
2005-1-24
|
pubmed:abstractText |
We investigated the expression of 50 cytochrome P450 (CYP) genes in the postischemic reperfused rat liver using a DNA microarray. Thirteen CYPs showed absent expression in all experiments and 2 CYPs were induced by pentobarbital, which was used as an anesthetic. Eight of the remaining 35 CYPs showed significantly decreased expression following ischemia-reperfusion. Monitoring CYP expression may be a powerful approach for elucidation of pathways regulating drug metabolism that may be involved in postischemic reperfusion liver injury.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
1347-8613
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
97
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
153-6
|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15655285-Animals,
pubmed-meshheading:15655285-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:15655285-Cytochrome P-450 CYP2B1,
pubmed-meshheading:15655285-Liver,
pubmed-meshheading:15655285-Male,
pubmed-meshheading:15655285-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:15655285-Phenobarbital,
pubmed-meshheading:15655285-Rats,
pubmed-meshheading:15655285-Rats, Inbred WKY,
pubmed-meshheading:15655285-Reperfusion Injury,
pubmed-meshheading:15655285-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15655285-Steroid Hydroxylases,
pubmed-meshheading:15655285-Up-Regulation
|
pubmed:year |
2005
|
pubmed:articleTitle |
Monitoring expression of cytochrome P450 genes during postischemic rat liver reperfusion using DNA microarrays.
|
pubmed:affiliation |
Division of Genomic Epidemiology & Clinical Trials, Advanced Medical Research Center, Nihon University School of Medicine, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study
|