| pubmed-article:15654819 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15654819 | lifeskim:mentions | umls-concept:C0021368 | lld:lifeskim |
| pubmed-article:15654819 | lifeskim:mentions | umls-concept:C0597722 | lld:lifeskim |
| pubmed-article:15654819 | lifeskim:mentions | umls-concept:C0014939 | lld:lifeskim |
| pubmed-article:15654819 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:15654819 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:15654819 | lifeskim:mentions | umls-concept:C0301625 | lld:lifeskim |
| pubmed-article:15654819 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15654819 | pubmed:dateCreated | 2005-1-18 | lld:pubmed |
| pubmed-article:15654819 | pubmed:abstractText | Estrogen has extensive effects on the immune system. The aim of the present experiments was to compare the effects of 17beta-estradiol (E2) and 4-estren-3alpha,17beta-diol (estren) on T lymphopoiesis and T cell-dependent inflammation. In order to investigate the role of estrogen receptors (ER) in the effects of E2 and estren on the immune system, ER knock-out mice lacking both ERalpha and ERbeta (DERKO) were used. T lymphopoiesis and T cell-dependent inflammation were studied by investigating thymus cellularity, the delayed-type hypersensitivity (DTH) reaction, CD4(+) T cells in spleen and serum levels of interleukin (IL)-6. As expected, the presence of ERs was mandatory for all the effects of E2. In contrast, treatment with estren reduced thymus cellularity in ER knock-out mice, indicating an effect through ER-independent pathways. Interestingly, estren suppressed only DTH, the frequency of CD4(+) T cells in spleen and serum levels of IL-6 in wild-type (WT) mice, but not in mice lacking ERs. Thus, our study is the first to show that estren inhibits T lymphopoiesis via ER-independent pathways, whereas its suppressive effects on inflammation are ER-dependent. | lld:pubmed |
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| pubmed-article:15654819 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15654819 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15654819 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15654819 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15654819 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:15654819 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:15654819 | pubmed:author | pubmed-author:NilssonSS | lld:pubmed |
| pubmed-article:15654819 | pubmed:author | pubmed-author:CarlstenHH | lld:pubmed |
| pubmed-article:15654819 | pubmed:author | pubmed-author:OhlssonCC | lld:pubmed |
| pubmed-article:15654819 | pubmed:author | pubmed-author:ErlandssonM... | lld:pubmed |
| pubmed-article:15654819 | pubmed:author | pubmed-author:GustafssonJ-A... | lld:pubmed |
| pubmed-article:15654819 | pubmed:author | pubmed-author:MovérareSS | lld:pubmed |
| pubmed-article:15654819 | pubmed:author | pubmed-author:IslanderUU | lld:pubmed |
| pubmed-article:15654819 | pubmed:author | pubmed-author:ChavoshiTT | lld:pubmed |
| pubmed-article:15654819 | pubmed:author | pubmed-author:JochemsCC | lld:pubmed |
| pubmed-article:15654819 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15654819 | pubmed:volume | 139 | lld:pubmed |
| pubmed-article:15654819 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15654819 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15654819 | pubmed:pagination | 210-5 | lld:pubmed |
| pubmed-article:15654819 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:15654819 | pubmed:meshHeading | pubmed-meshheading:15654819... | lld:pubmed |
| pubmed-article:15654819 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15654819 | pubmed:articleTitle | Estren-mediated inhibition of T lymphopoiesis is estrogen receptor-independent whereas its suppression of T cell-mediated inflammation is estrogen receptor-dependent. | lld:pubmed |
| pubmed-article:15654819 | pubmed:affiliation | Department of Rheumatology and Inflammation Research at the Sahlgrenska Academy, Göteborg, Sweden. ulrika.islander@rheuma.gu.se | lld:pubmed |
| pubmed-article:15654819 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15654819 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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