Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2005-1-18
pubmed:abstractText
Estrogen has extensive effects on the immune system. The aim of the present experiments was to compare the effects of 17beta-estradiol (E2) and 4-estren-3alpha,17beta-diol (estren) on T lymphopoiesis and T cell-dependent inflammation. In order to investigate the role of estrogen receptors (ER) in the effects of E2 and estren on the immune system, ER knock-out mice lacking both ERalpha and ERbeta (DERKO) were used. T lymphopoiesis and T cell-dependent inflammation were studied by investigating thymus cellularity, the delayed-type hypersensitivity (DTH) reaction, CD4(+) T cells in spleen and serum levels of interleukin (IL)-6. As expected, the presence of ERs was mandatory for all the effects of E2. In contrast, treatment with estren reduced thymus cellularity in ER knock-out mice, indicating an effect through ER-independent pathways. Interestingly, estren suppressed only DTH, the frequency of CD4(+) T cells in spleen and serum levels of IL-6 in wild-type (WT) mice, but not in mice lacking ERs. Thus, our study is the first to show that estren inhibits T lymphopoiesis via ER-independent pathways, whereas its suppressive effects on inflammation are ER-dependent.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/15654819-10805804, http://linkedlifedata.com/resource/pubmed/commentcorrection/15654819-10811854, http://linkedlifedata.com/resource/pubmed/commentcorrection/15654819-11257226, http://linkedlifedata.com/resource/pubmed/commentcorrection/15654819-11380688, http://linkedlifedata.com/resource/pubmed/commentcorrection/15654819-11739008, http://linkedlifedata.com/resource/pubmed/commentcorrection/15654819-11834456, http://linkedlifedata.com/resource/pubmed/commentcorrection/15654819-12234628, http://linkedlifedata.com/resource/pubmed/commentcorrection/15654819-12399595, http://linkedlifedata.com/resource/pubmed/commentcorrection/15654819-12740446, http://linkedlifedata.com/resource/pubmed/commentcorrection/15654819-12782668, http://linkedlifedata.com/resource/pubmed/commentcorrection/15654819-12858441, http://linkedlifedata.com/resource/pubmed/commentcorrection/15654819-12941152, http://linkedlifedata.com/resource/pubmed/commentcorrection/15654819-14645673, http://linkedlifedata.com/resource/pubmed/commentcorrection/15654819-14745006, http://linkedlifedata.com/resource/pubmed/commentcorrection/15654819-14764654, http://linkedlifedata.com/resource/pubmed/commentcorrection/15654819-1586960, http://linkedlifedata.com/resource/pubmed/commentcorrection/15654819-2422449, http://linkedlifedata.com/resource/pubmed/commentcorrection/15654819-2753520, http://linkedlifedata.com/resource/pubmed/commentcorrection/15654819-2807378, http://linkedlifedata.com/resource/pubmed/commentcorrection/15654819-3501349, http://linkedlifedata.com/resource/pubmed/commentcorrection/15654819-4908652, http://linkedlifedata.com/resource/pubmed/commentcorrection/15654819-6609869, http://linkedlifedata.com/resource/pubmed/commentcorrection/15654819-8046347, http://linkedlifedata.com/resource/pubmed/commentcorrection/15654819-8202495, http://linkedlifedata.com/resource/pubmed/commentcorrection/15654819-8228804, http://linkedlifedata.com/resource/pubmed/commentcorrection/15654819-8248223, http://linkedlifedata.com/resource/pubmed/commentcorrection/15654819-8650195, http://linkedlifedata.com/resource/pubmed/commentcorrection/15654819-8821775, http://linkedlifedata.com/resource/pubmed/commentcorrection/15654819-8955504, http://linkedlifedata.com/resource/pubmed/commentcorrection/15654819-9427047, http://linkedlifedata.com/resource/pubmed/commentcorrection/15654819-9514700, http://linkedlifedata.com/resource/pubmed/commentcorrection/15654819-9861029
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0009-9104
pubmed:author
pubmed:issnType
Print
pubmed:volume
139
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
210-5
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Estren-mediated inhibition of T lymphopoiesis is estrogen receptor-independent whereas its suppression of T cell-mediated inflammation is estrogen receptor-dependent.
pubmed:affiliation
Department of Rheumatology and Inflammation Research at the Sahlgrenska Academy, Göteborg, Sweden. ulrika.islander@rheuma.gu.se
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't