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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2005-3-21
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pubmed:abstractText |
The androgen receptor (AR) is activated in prostate cancer patients undergoing androgen ablative therapy and mediates growth of androgen-insensitive prostate cancer cells, suggesting it is activated by nonandrogenic factors. We demonstrate that activated alpha subunit of heterotrimeric guanine nucleotide-binding G(s) protein activates the AR in prostate cancer cells and also synergizes with low concentration of androgen to more fully activate the AR. The G alpha(s) activates protein kinase A, which is required for the nuclear partition and activation of AR. These data suggest a role for G alpha(s) and PKA in the transactivation of AR in prostate cancer cells under the environment of reduced androgen levels.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0021-9258
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
25
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pubmed:volume |
280
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
11583-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15653681-Cyclic AMP,
pubmed-meshheading:15653681-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:15653681-Dihydrotestosterone,
pubmed-meshheading:15653681-GTP-Binding Protein alpha Subunits, Gs,
pubmed-meshheading:15653681-Humans,
pubmed-meshheading:15653681-Isoproterenol,
pubmed-meshheading:15653681-Male,
pubmed-meshheading:15653681-Prostatic Neoplasms,
pubmed-meshheading:15653681-Receptors, Adrenergic, beta-2,
pubmed-meshheading:15653681-Receptors, Androgen,
pubmed-meshheading:15653681-Signal Transduction
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pubmed:year |
2005
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pubmed:articleTitle |
Androgen receptor activation by G(s) signaling in prostate cancer cells.
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pubmed:affiliation |
Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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