Linked Life Data

15652605

Source:http://linkedlifedata.com/resource/pubmed/id/15652605

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9455
pubmed:dateCreated
2005-1-17
pubmed:abstractText
Individuals homozygous for the T allele of the MTHFR C677T polymorphism have higher plasma homocysteine concentrations (the phenotype) than those with the CC genotype, which, if pathogenetic, should put them at increased risk of stroke. Since this polymorphism is distributed randomly during gamete formation, its association with stroke should not be biased or confounded. We investigated consistency between the expected odds ratio for stroke among TT homozygotes, extrapolated from genotype-phenotype and phenotype-disease studies, and the observed odds ratio from a meta-analysis of genotype-disease association studies.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1474-547X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
365
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
224-32
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:articleTitle
Homocysteine and stroke: evidence on a causal link from mendelian randomisation.
pubmed:affiliation
Centre for Clinical Pharmacology, Department of Medicine, British Heart Foundation Laboratories, Royal Free and University College Medical School, University College London, Rayne Building, 5 University Street, London WC1E 6 JJ, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Meta-Analysis