|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0006863,
umls-concept:C0008018,
umls-concept:C0024432,
umls-concept:C0024808,
umls-concept:C0085295,
umls-concept:C0449432,
umls-concept:C0591833,
umls-concept:C1179435,
umls-concept:C1515655,
umls-concept:C1524073,
umls-concept:C1533691,
umls-concept:C1548799,
umls-concept:C1705248,
umls-concept:C1819439
|
|
pubmed:issue |
1-2
|
|
pubmed:dateCreated |
2005-1-17
|
|
pubmed:abstractText |
Cannabidiol is the main nonpsychoactive component of marijuana. We examined the ability of in vivo and in vitro cannabidiol to interfere with the production of interleukin (IL)-12 and IL-10 by murine macrophages and to modulate macrophage chemotaxis. Cannabidiol added in vitro to peritoneal macrophages significantly increased IL-12 and decreased IL-10 production. The CB1 and CB2 receptor antagonists prevented this modulation. Macrophages from animals treated with cannabidiol at the dose of 30 mg kg(-1) either orally or i.p. produced higher levels of IL-12 and lower levels of IL-10 in comparison to controls, and the CB receptor antagonists did not prevent these effects. Cannabidiol dose-dependently decreased fMLP-induced chemotaxis of macrophages, and the CB2 receptor antagonist prevented this decrease.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Bornanes,
http://linkedlifedata.com/resource/pubmed/chemical/Cannabidiol,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/Piperidines,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Cannabinoid, CB1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Cannabinoid, CB2,
http://linkedlifedata.com/resource/pubmed/chemical/SR 144528,
http://linkedlifedata.com/resource/pubmed/chemical/rimonabant
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0165-5728
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
159
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
97-105
|
|
pubmed:dateRevised |
2007-10-17
|
|
pubmed:meshHeading |
pubmed-meshheading:15652407-Adjuvants, Immunologic,
pubmed-meshheading:15652407-Administration, Oral,
pubmed-meshheading:15652407-Animals,
pubmed-meshheading:15652407-Bornanes,
pubmed-meshheading:15652407-Cannabidiol,
pubmed-meshheading:15652407-Cell Migration Inhibition,
pubmed-meshheading:15652407-Cells, Cultured,
pubmed-meshheading:15652407-Chemotaxis,
pubmed-meshheading:15652407-Cytokines,
pubmed-meshheading:15652407-Down-Regulation,
pubmed-meshheading:15652407-Interleukin-10,
pubmed-meshheading:15652407-Interleukin-12,
pubmed-meshheading:15652407-Macrophage Activation,
pubmed-meshheading:15652407-Macrophages, Peritoneal,
pubmed-meshheading:15652407-Male,
pubmed-meshheading:15652407-Mice,
pubmed-meshheading:15652407-Piperidines,
pubmed-meshheading:15652407-Pyrazoles,
pubmed-meshheading:15652407-Receptor, Cannabinoid, CB1,
pubmed-meshheading:15652407-Receptor, Cannabinoid, CB2,
pubmed-meshheading:15652407-Up-Regulation
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
The nonpsychoactive component of marijuana cannabidiol modulates chemotaxis and IL-10 and IL-12 production of murine macrophages both in vivo and in vitro.
|
|
pubmed:affiliation |
Department of Pharmacology, via Vanvitelli 32, 20129 Milano, Italy. paola.sacerdote@unimi.it
|
|
pubmed:publicationType |
Journal Article
|
