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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2005-1-17
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pubmed:abstractText |
The effects of interferon (IFN)-beta used for treatment of multiple sclerosis (MS) on the central nervous system (CNS) have not yet been elucidated. The effect of IFN-beta and IFN-gamma on astrocytes as the major component of the CNS was investigated using murine primary astrocytes and human astrocytoma U251 cell line. IL-1beta, IL-6, TNF-alpha and iNOS were analyzed by RT-PCR. Both protein and mRNA levels of IL-6 were increased by IFN-beta. IFN-gamma augmented the effect of IFN-beta on IL-6 production. These results suggest that IFN-beta has an activity to modulate inflammatory and immune responses by up-regulating IL-6 in the CNS of MS.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-beta,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0165-5728
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
159
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
48-54
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:15652402-Adjuvants, Immunologic,
pubmed-meshheading:15652402-Animals,
pubmed-meshheading:15652402-Astrocytes,
pubmed-meshheading:15652402-Cell Line, Tumor,
pubmed-meshheading:15652402-Cells, Cultured,
pubmed-meshheading:15652402-Cytokines,
pubmed-meshheading:15652402-Dose-Response Relationship, Immunologic,
pubmed-meshheading:15652402-Humans,
pubmed-meshheading:15652402-Interferon Type I,
pubmed-meshheading:15652402-Interferon-beta,
pubmed-meshheading:15652402-Interferon-gamma,
pubmed-meshheading:15652402-Interleukin-1,
pubmed-meshheading:15652402-Interleukin-6,
pubmed-meshheading:15652402-Mice,
pubmed-meshheading:15652402-Mice, Inbred C57BL,
pubmed-meshheading:15652402-Mice, Knockout,
pubmed-meshheading:15652402-Nitric Oxide,
pubmed-meshheading:15652402-RNA, Messenger,
pubmed-meshheading:15652402-Recombinant Proteins,
pubmed-meshheading:15652402-Tumor Necrosis Factor-alpha
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pubmed:year |
2005
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pubmed:articleTitle |
Effects of interferon-beta on the cytokine production of astrocytes.
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pubmed:affiliation |
Department of Neurology, School of Medicine, University of Occupational and Environmental Health, Yahatanishiku, Kitakyushu 807-8555, Japan. gion@med.uoeh-u.ac.jp
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pubmed:publicationType |
Journal Article
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