Linked Life Data

15651564

Source:http://linkedlifedata.com/resource/pubmed/id/15651564

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2005-1-17
pubmed:abstractText
Excitable media theory predicts the effect of electrical wavefront morphology on the dynamics of propagation in cardiac tissue. It specifies that a convex wavefront propagates slower and a concave wavefront propagates faster than a planar wavefront. Because of this, wavefront curvature is thought to be an important functional mechanism of cardiac arrhythmias. However, the curvature of wavefronts during an arrhythmia are generally unknown. We introduce a robust, automated method to measure the curvature vector field of discretely characterized, arbitrarily shaped, two-dimensional (2-D) wavefronts. The method relies on generating a smooth, continuous parameterization of the shape of a wave using cubic smoothing splines fitted to an isopotential at a specified level, which we choose to be -30 mV. Twice differentiating the parametric form provides local curvature vectors along the wavefront and waveback. Local conduction velocities are computed as the wave speed along lines normal to the parametric form. In this way, the curvature and velocity vector field for wavefronts and wavebacks can be measured. We applied the method to data sampled from a 2-D numerical model and several examples are provided to illustrate its usefulness for studying the dynamics of cardiac propagation in 2-D media.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0018-9294
pubmed:author
pubmed:issnType
Print
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
50-63
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Measuring curvature and velocity vector fields for waves of cardiac excitation in 2-D media.
pubmed:affiliation
Department of Biomedical Engineering, University of Alabama at Birmingham, 1530 Third Ave. South, B140 Volker Hall, Birmingham, AL 35294-0019, USA. mwk@crml.uab.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't