| pubmed-article:15649569 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15649569 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:15649569 | lifeskim:mentions | umls-concept:C0013935 | lld:lifeskim |
| pubmed-article:15649569 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:15649569 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:15649569 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:15649569 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15649569 | pubmed:dateCreated | 2005-1-14 | lld:pubmed |
| pubmed-article:15649569 | pubmed:abstractText | It has been reported that diabetes-induced inappropriate apoptosis in embryos during neurulation may be one of the mechanisms leading to neural tube defects. We studied apoptosis and the apoptotic pathway occurring in early post-implantation period embryos of non-diabetic and streptozotocin (STZ)-induced diabetic rats. In quantitative RT-PCR, bax mRNA was constantly expressed to similar degree in embryos of non-diabetic and diabetic rats, while the expression of bcl-2 mRNA was significantly decreased in diabetic rat embryos compared to non-diabetic rat embryos. The increased number of terminal deoxynucleotidyl transferase-mediated nick end labeling (TUNEL)-positive cells occurred selectively in the primitive brains of diabetic rat embryos compared to non-diabetic rat embryos. Immunohistochemical studies revealed that, in mirror sections, the staining of Bax and activated caspase-3 were observed in the TUNEL-positive cell area, but the expression of Bcl-2 in these apoptotic cells was generally too low to be detected. These results suggest that a Bax-regulated mitochondrial cytochrome c-mediated caspase-3 activation pathway might be involved in the diabetic embryopathy. | lld:pubmed |
| pubmed-article:15649569 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15649569 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15649569 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15649569 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15649569 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15649569 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15649569 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15649569 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:15649569 | pubmed:issn | 0168-8227 | lld:pubmed |
| pubmed-article:15649569 | pubmed:author | pubmed-author:SugaharaKazuy... | lld:pubmed |
| pubmed-article:15649569 | pubmed:author | pubmed-author:KamihiraShime... | lld:pubmed |
| pubmed-article:15649569 | pubmed:author | pubmed-author:EguchiKatsumi... | lld:pubmed |
| pubmed-article:15649569 | pubmed:author | pubmed-author:KojiTakehikoT | lld:pubmed |
| pubmed-article:15649569 | pubmed:author | pubmed-author:KawasakiEijiE | lld:pubmed |
| pubmed-article:15649569 | pubmed:author | pubmed-author:SunFuyanF | lld:pubmed |
| pubmed-article:15649569 | pubmed:author | pubmed-author:AkazawaShoich... | lld:pubmed |
| pubmed-article:15649569 | pubmed:author | pubmed-author:HishikawaYosi... | lld:pubmed |
| pubmed-article:15649569 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15649569 | pubmed:volume | 67 | lld:pubmed |
| pubmed-article:15649569 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15649569 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15649569 | pubmed:pagination | 110-8 | lld:pubmed |
| pubmed-article:15649569 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:15649569 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15649569 | pubmed:articleTitle | Apoptosis and its pathway in early post-implantation embryos of diabetic rats. | lld:pubmed |
| pubmed-article:15649569 | pubmed:affiliation | Department of Metabolism/Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry, Nagasaki, Japan. | lld:pubmed |
| pubmed-article:15649569 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:24224 | entrezgene:pubmed | pubmed-article:15649569 | lld:entrezgene |
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