Source:http://linkedlifedata.com/resource/pubmed/id/15649255
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rdf:type | |
lifeskim:mentions |
umls-concept:C0007589,
umls-concept:C0449560,
umls-concept:C0450094,
umls-concept:C0687697,
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umls-concept:C1414313,
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umls-concept:C1514559,
umls-concept:C1518435,
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umls-concept:C1690540,
umls-concept:C1707520,
umls-concept:C1883548,
umls-concept:C2919019
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pubmed:issue |
1
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pubmed:dateCreated |
2005-1-14
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pubmed:abstractText |
Although KIT and EGFR overexpressions are reported to occur in breast cancer, their pathological significance is still unclear. We examined KIT, EGFR, and c-erbB-2 overexpressions immunohistochemically in 150 cases of surgically resected breast cancer and their correlation with the histological type and grade and mesenchymal and/or myoepithelial immunophenotype of primary tumors. To facilitate the analysis, we constructed a tissue microarray comprising 2-mm diameter tissues cored from the representative tissue block of each tumor. KIT, EGFR, and c-erbB-2 overexpressions were detected in 15 (10%), 12 (8%), and 23 (15%), respectively. The KIT was more frequent in the group comprising comedo-type ductal carcinoma in situ and invasive ductal carcinomas (IDCs) of the solid-tubular subtype than in the group of other histological types (P=0.027), and the EGFR was more frequent in IDCs of solid-tubular type than in other histological types (P <0.05). KIT and EGFR overexpressions were correlated with nuclear grade 3 (P=0.0095 and 0.0005) and tended to be concurrent (P=0.005). KIT overexpression was correlated with vimentin and S-100 expression (P=0.003 and P=0.005), and EGFR overexpression was correlated with S100 expression (P=0.0001). These correlations with grade and mesenchymal/myoepithelial markers were not observed for c-erbB-2 overexpression. KIT and EGFR appeared to be indicators of high-grade breast carcinoma groups that often contain the carcinomas with mesenchymal and/or myoepithelial differentiation, which are distinct from the group with c-erbB-2 overexpression.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-kit,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, erbB-2,
http://linkedlifedata.com/resource/pubmed/chemical/S100 Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/Vimentin
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1347-9032
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pubmed:author |
pubmed-author:HiraideHoshioH,
pubmed-author:InazawaJohjiJ,
pubmed-author:KimuraMikihikoM,
pubmed-author:MatsubaraOsamuO,
pubmed-author:MochizukiHidetakaH,
pubmed-author:MoritaDaisakuD,
pubmed-author:OhtsukaYukikoY,
pubmed-author:ShintoEijiE,
pubmed-author:TamaiSeiichiS,
pubmed-author:TamakiKuniyoshiK,
pubmed-author:TsudaHitoshiH
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pubmed:issnType |
Print
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pubmed:volume |
96
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
48-53
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15649255-Breast Neoplasms,
pubmed-meshheading:15649255-Carcinoma, Ductal, Breast,
pubmed-meshheading:15649255-Humans,
pubmed-meshheading:15649255-Immunohistochemistry,
pubmed-meshheading:15649255-Proto-Oncogene Proteins c-kit,
pubmed-meshheading:15649255-Receptor, Epidermal Growth Factor,
pubmed-meshheading:15649255-Receptor, erbB-2,
pubmed-meshheading:15649255-S100 Proteins,
pubmed-meshheading:15649255-Tumor Markers, Biological,
pubmed-meshheading:15649255-Up-Regulation,
pubmed-meshheading:15649255-Vimentin
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pubmed:year |
2005
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pubmed:articleTitle |
Correlation of KIT and EGFR overexpression with invasive ductal breast carcinoma of the solid-tubular subtype, nuclear grade 3, and mesenchymal or myoepithelial differentiation.
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pubmed:affiliation |
Department of Pathology II, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513. htsuda@cc.ndmc.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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