Source:http://linkedlifedata.com/resource/pubmed/id/15648070
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2005-1-18
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| pubmed:abstractText |
HIV-1 infections due to non-B subtypes are increasing rapidly in number and spreading across Europe. The genetic nature of HIV-1 non-B variants containing subtype G sequences at the protease (PR)-coding region are described from 48 unrelated subjects living in Spain. Phylogenetic analyses of the HIV-1 reverse transcriptase (RT) and envelope (env) genes (including the V3 loop) were performed. Up to 32 (66.6%) of samples carried inter-subtype recombinant viruses. Although double recombinants were found most frequently (G/A in 20; G/B in 8; G/K in 2), two individuals harbored triple recombinant viruses (GPR/BRT/Aenv and GPR/KRT/Aenv, respectively). Only 33 (68.7%) and 9 (18.7%) sequences clustered with clade G when examining the RT and env genes, respectively. Nearly 70% of samples with pol sequences (PR/RT) belonging to subtype G harbored env sequences ascribed to other clades: A (55.6%), B (11.1%), or K (3.7%). Of note, most recombinant viruses clustered with CRF02_AG, although CRF14_BG recombinants were also found. This study demonstrates that most viruses circulating in Spain with clade G sequences at the pol-coding region are in fact inter-subtype recombinants, with CRF02_AG being the most prevalent virus.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
0146-6615
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| pubmed:author | |
| pubmed:copyrightInfo |
2005 Wiley-Liss, Inc.
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| pubmed:issnType |
Print
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| pubmed:volume |
75
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
374-80
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| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:15648070-Adolescent,
pubmed-meshheading:15648070-Adult,
pubmed-meshheading:15648070-DNA, Complementary,
pubmed-meshheading:15648070-DNA, Viral,
pubmed-meshheading:15648070-Female,
pubmed-meshheading:15648070-Genes, env,
pubmed-meshheading:15648070-HIV Infections,
pubmed-meshheading:15648070-HIV Protease,
pubmed-meshheading:15648070-HIV Reverse Transcriptase,
pubmed-meshheading:15648070-HIV-1,
pubmed-meshheading:15648070-Humans,
pubmed-meshheading:15648070-Male,
pubmed-meshheading:15648070-Middle Aged,
pubmed-meshheading:15648070-Molecular Epidemiology,
pubmed-meshheading:15648070-Molecular Sequence Data,
pubmed-meshheading:15648070-Phylogeny,
pubmed-meshheading:15648070-Recombination, Genetic,
pubmed-meshheading:15648070-Sequence Analysis, DNA,
pubmed-meshheading:15648070-Sequence Homology,
pubmed-meshheading:15648070-Spain
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| pubmed:year |
2005
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| pubmed:articleTitle |
Heterogeneous nature of HIV-1 recombinants spreading in Spain.
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| pubmed:affiliation |
Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain. aholguin.hciii@salud.madrid.org
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|