Linked Life Data

15647491

Source:http://linkedlifedata.com/resource/pubmed/id/15647491

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2005-1-13
pubmed:abstractText
The paradigm task A-->task B-->task A, which varies the time interval between task A and task B, has been used extensively to investigate the consolidation of motor memory. Consolidation is defined as resistance to retrograde interference (interference by task B on initial learning of task A). Consolidation has been demonstrated for simple skills, motor sequencing, and learning of force fields. In contrast, evidence to date suggests that visuomotor learning does not consolidate. We have shown previously that adaptation to a 30 degrees screen-cursor rotation is faster and more complete on relearning 24 hr later. This improvement is prevented if a 30 degrees counter-rotation is learned 5 min after the original rotation. Here, we sought to identify conditions under which rotation learning becomes resistant to interference by a counter-rotation. In experiment 1, we found that interference persists even when the counter-rotation is learned 24 hr after the initial rotation. In experiment 2, we removed potential anterograde interference (interference by task B on relearning of task A) by introducing washout blocks before all of the learning blocks. In contrast to experiment 1, we found resistance to interference (i.e., consolidation) when the counter-rotation was learned after 24 hr but not after 5 min. In experiment 3, we doubled the amount of initial rotation learning and found resistance to interference even after 5 min. Our results suggest that persistent interference is attributable to anterograde effects on memory retrieval. When anterograde effects are removed, rotation learning consolidates both over time and with increased initial training.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
12
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
473-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Adaptation to visuomotor transformations: consolidation, interference, and forgetting.
pubmed:affiliation
Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York 10032-2603, USA.
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, U.S. Gov't, P.H.S., Randomized Controlled Trial, Research Support, N.I.H., Extramural