Linked Life Data

15646859

Source:http://linkedlifedata.com/resource/pubmed/id/15646859

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
52
pubmed:dateCreated
2005-1-13
pubmed:abstractText
This year's Nobel Prize in Chemistry has been awarded to Aaron Ciechanover, Avram Herskho and Irwin Rose for the discovery of ubiquitin-mediated protein degradation. In a series of groundbreaking experiments these scientists described the basic principles for a unique posttranslational modification based on the conjugation of the small protein ubiquitin to proteins deemed for degradation. Although ubiquitin started in 1980 as an unusual modification of certain proteins, it is now clear that it functions as a signal for degradation when it forms a polymer. Hundreds of proteins are involved in the controlled destruction of ubiquitin-labelled proteins in the cell. And hundreds of other proteins are involved in protein modification by mono-ubiquitin, so that other processes, such as the formation of another degradation compartment, the lysosome, can proceed normally.
pubmed:language
dut
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0028-2162
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
148
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2579-82
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
[The 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation].
pubmed:affiliation
Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis, divisie Tumorbiologie, Plesmanlaan 121, 1066 CX Amsterdam.
pubmed:publicationType
Journal Article, Biography, English Abstract, Historical Article, Research Support, Non-U.S. Gov't